The emergent role of mitochondrial RNA modifications in metabolic alterations

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dc.authorid0000-0002-2014-6635en_US
dc.authorscopusid22733342800en_US
dc.authorwosid-en_US
dc.contributor.authorBoughanem, Hatim
dc.contributor.authorBottcher, Yvonne
dc.contributor.authorTome-Carneiro, Joao
dc.contributor.authorLopez de Las Hazas, Maria-Carmen
dc.contributor.authorDavalos, Alberto
dc.contributor.authorÇayır, Akın
dc.contributor.authorMacias-Gonzalez, Manuel
dc.date.accessioned2023-08-21T08:20:57Z
dc.date.available2023-08-21T08:20:57Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractMitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial evidence indicates that they play a critical role in accurate protein synthesis. Recent evidence supported those modifications in mitochondrial RNAs also have crucial implications in mitochondrial-related diseases. In the light of current knowledge about the involvement, the association between mitochondrial RNA modifications and diseases arises from studies focusing on mutations in both mitochondrial and nuclear DNA genes encoding enzymes involved in such modifications. Here, we review the current evidence available for mitochondrial RNA modifications and their role in metabolic disorders, and we also explore the possibility of using them as promising targets for prevention and early detection. Finally, we discuss future directions of mitochondrial epitranscriptomics in these metabolic alterations, and how these RNA modifications may offer a new diagnostic and theragnostic avenue for preventive purposes. This article is categorized under: RNA Processing > RNA Editing and Modification.en_US
dc.identifier.citationBoughanem, H., Böttcher, Y., Tomé-Carneiro, J., Lopez de Las Hazas, M.-C., Çayır, A., & Macias-Gonzalez, M. (2023). The emergent role of mitochondrial RNA modifications in metabolic alterations. Wiley Interdisciplinary Reviews: RNA, 14(2). https://doi.org/10.1002/wrna.1753 ‌en_US
dc.identifier.doi10.1002/wrna.1753
dc.identifier.issn1757-7004
dc.identifier.issn1757-7012
dc.identifier.issue2en_US
dc.identifier.pmid35872632
dc.identifier.scopus2-s2.0-85134559090
dc.identifier.urihttps://doi.org/10.1002/wrna.1753
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4506
dc.identifier.volume14en_US
dc.identifier.wosWOS:000829296900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇayır, Akın
dc.language.isoen
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofWiley Interdisciplinary Reviews: RNAen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectEpitranscriptomicsen_US
dc.subjectMetabolic alterationsen_US
dc.subjectMetabolismen_US
dc.subjectMitochondriaen_US
dc.subjectRNA modificationsen_US
dc.titleThe emergent role of mitochondrial RNA modifications in metabolic alterations
dc.typeReview Article

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