An Insidious Clinical Picture: Optic Nerve Involvement in Patients with COVID-19

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dc.contributor.authorOcak, Ozgul
dc.contributor.authorŞahin, Erkan Melih
dc.contributor.authorSener, Alper
dc.contributor.authorOcak, Baris
dc.date.accessioned2025-01-27T21:20:04Z
dc.date.available2025-01-27T21:20:04Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Many neurological symptoms due to central nervous system, peripheral nervous system and musculoskeletal system damage have been reported in more than a third of patients with coronavirus disease-2019 (COVID-19). Although optic neuritis has been reported in patients with COVID-19, they are extremely rare. The aim of this study was screening optic nerve involvement in COVID-19 with visual evoked potential (VEP) in asymptomatic patients without a history of visual impairment. Materials and Methods: Pattern reversal VEP measurements were made in 101 adult patients with COVID-19 without a history of visual impairment after they completed COVID-19 treatments and the quarantine period. VEPs were recorded with the 4-channel electromyography-evoked device in a dark room. P100 latencies and amplitudes were analyzed by the same neurologist. Results: A total of 34 (33.7%) patients had P100 latency prolongation. There was no significant difference in terms of gender, age or outpatient/inpatient treatment status. There was no significant correlation between the time of polymerase chain reaction diagnosis and VEP values. Conclusion: Contrary to previous studies, asymptomatic optic nerve involvement after COVID-19 was detected by VEP measurements. Prolongation of P100 latency shows the probable linkage between COVID-19 virus and angiotensin converting enzyme 2 receptors in human eyes.
dc.identifier.doi10.4274/tnd.2022.67026
dc.identifier.endpage161
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85150371049
dc.identifier.scopusqualityQ4
dc.identifier.startpage158
dc.identifier.trdizinid1173607
dc.identifier.urihttps://doi.org/10.4274/tnd.2022.67026
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1173607
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28810
dc.identifier.volume28
dc.identifier.wosWOS:000916443200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCOVID-19 virus infection
dc.subjectoptic nerve
dc.subjectVEP
dc.titleAn Insidious Clinical Picture: Optic Nerve Involvement in Patients with COVID-19
dc.title.alternativeSinsi Bir Klinik Tablo: COVID-19’lu Hastalarda Optik Sinir Tutulumu
dc.typeArticle

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