Hyaluronic acid (HA)-Gd(III) and HA-Fe(III) microgels as MRI contrast enhancing agents

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dc.authorscopusid6602001525en_US
dc.authorscopusid57210429765en_US
dc.authorscopusid24472372400en_US
dc.authorwosidKVP-4764-2024en_US
dc.authorwosidU-5886-2019en_US
dc.authorwosidAAB-6714-2020en_US
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorUmut, Evrim
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorCulha, Mustafa
dc.contributor.authorAyyala, Ramesh S.
dc.date.accessioned2025-02-06T09:05:23Z
dc.date.available2025-02-06T09:05:23Z
dc.date.issued2022en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümüen_US
dc.departmentÇanakkale Uygulamalı Bilimler Yüksekokulu, Moda Tararım Bölümüen_US
dc.description.abstractHyaluronic acid (HA) was crosslinked with Gd(III) and Fe(III) ions rendering physically crosslinked HA-metal(III) microgels as magnetic resonance imaging (MRI) enhancing contrast agents. These HA-Gd(III) and HA-Fe(III) microgels are injectable with size range, 50–5000 nm in water. The same isoelectric point, pH 1.2 ± 0.1, was measured for both microgels. HA-Gd(III) and HA-Fe(III) microgels are hemo-compatible biomaterials and can be safely used in intravascular applications up to 1000 μg/mL concentration. Furthermore, no significant toxicity was attained as 95 ± 8 and 81 ± 2% cell viability on L929 fibroblast cells at 100 μg/mL of HA-Gd(III) and HA-Fe(III) microgels were measured. Moreover, HA-Gd(III) microgels were found to afford significant contrast improvement capability in MRI with proton relaxivity, r1 = 2.11 mM−1 s−1, comparable with the values reported for Gd(III) labeled functionalized HA gel systems and commercial Gd based contrast agents.en_US
dc.identifier.citationŞahiner, N., Umut, E., Sağbaş Suner, S., Şahiner, M., Culha, M., & Ayyala, R. S. (2022). Hyaluronic acid (HA)-Gd(III) and HA-Fe(III) microgels as MRI contrast enhancing agents. Carbohydrate Polymers, 277. https://doi.org/10.1016/j.carbpol.2021.118873en_US
dc.identifier.doi10.1016/j.carbpol.2021.118873en_US
dc.identifier.endpage10en_US
dc.identifier.issn0144-8617 / 1879-1344
dc.identifier.pmidPMID: 34893278en_US
dc.identifier.scopus2-s2.0-85119953736en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2021.118873
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29554
dc.identifier.volume277en_US
dc.identifier.wosWOS:000761128400009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahiner, Nurettin
dc.institutionauthorSağbaş Suner, Selin
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorid0000-0003-0120-530X
dc.institutionauthorid0000-0002-3524-0675
dc.institutionauthorid0000-0001-8666-7954
dc.language.isoengen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofCarbohydrate Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood compatibleen_US
dc.subjectFe(II) chelatingen_US
dc.subjectHA-Fe(III) microgelen_US
dc.subjectHA-Gd(III) microgelen_US
dc.subjectHyaluronic acid (HA)en_US
dc.subjectMagnetic resonance imaging (MRI)en_US
dc.titleHyaluronic acid (HA)-Gd(III) and HA-Fe(III) microgels as MRI contrast enhancing agentsen_US
dc.typearticleen_US

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