Nanoparticles for Biomedical Use Derived from Natural Biomolecules: Tannic Acid and Arginine

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dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbas Suner, Selin / 0000-0002-3524-0675
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSağbas Suner, Selin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-05-29T02:57:24Z
dc.date.available2025-05-29T02:57:24Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.descriptionThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractBackground/Objectives: Tannic acid (TA) is a well-known natural phenolic acid composed of ten gallic acids linked to each other with ester bonding possessing excellent antioxidant properties in addition to antimicrobial and anticancer characteristics. Arginine (ARG) is a positively charged amino acid at physiological pH because of nitrogen-rich side chain. Method: Here, poly(tannic acid-co-arginine) (p(TA-co-ARG)) particles at three mole ratios, TA:ARG = 1:1, 1:2, and 1:3, were prepared via a Mannich condensation reaction between TA and ARG by utilizing formaldehyde as a linking agent. Results: The p(TA-co-ARG) particles in 300-1000 nm size range with smooth surfaces visualized via SEM analysis were attained. Abundant numbers of functional groups, -OH, -NH2, and -COOH stemming from TA and ARG constituent confirmed by FT-IR analysis. The isoelectric point (IEP) of the particles increased from pH 4.98 to pH 7.30 by increasing the ARG ratios in p(TA-co-ARG) particles. The antioxidant capacity of p(TA-co-ARG) particles via gallic acid (GA) and rosmarinic acid (RA) equivalents tests revealed that particles possess concentration-dependent antioxidant potency and increased by TA content. The alpha-glucosidase inhibition of p(TA-co-ARG) particles (2 mg/mL) 1:1 and 1:2 mole ratios revealed significant enzyme inhibition ability, e.g., 91.3 +/- 3.1% and 77.6 +/- 12.0%. Interestingly, p(TA-co-ARG) (1:3 ratio) possessed significant antibacterial effectiveness against Escherichia coli (ATCC 8739) and Staphylococcus aureus (ATCC 6538) bacteria. Furthermore, all p(TA-co-ARG) particles at 1000 mg/mL concentration showed >80% toxicity on L929 fibroblast cells and increased as ARG content of p(TA-co-ARG) particles is increased. Conclusions: p(TA-co-ARG) showed significant potential as natural biomaterials for biomedical use.
dc.identifier.doi10.3390/biomedicines13010209
dc.identifier.issn2227-9059
dc.identifier.issue1
dc.identifier.pmid39857792
dc.identifier.scopus2-s2.0-85215655689
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/biomedicines13010209
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30048
dc.identifier.volume13
dc.identifier.wosWOS:001405949900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofBiomedicines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjecttannic acid
dc.subjectarginine
dc.subjectnanoparticles
dc.subjectphenolic- and amino acid-based particles
dc.subjectantioxidant
dc.subjectantimicrobial
dc.subjectnanogel/microgel
dc.titleNanoparticles for Biomedical Use Derived from Natural Biomolecules: Tannic Acid and Arginine
dc.typeArticle

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