Melatonin ameliorates cisplatin-induced neurodegeneration in medulla oblongata through the expressions of Aqp-1,-4, inflammation, and apoptosis pathway genes

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dc.authoridOztopuz, Ozlem/0000-0002-1373-6311
dc.contributor.authorOztopuz, Ozlem
dc.date.accessioned2025-01-27T21:05:31Z
dc.date.available2025-01-27T21:05:31Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, the neuroprotective effects of melatonin (MEL) with changes in apoptosis, inflammation, and histopathological morphology were evaluated in the medulla oblongata of cisplatin (CIS) administered rats. Although the side effects of CIS are known in many tissues, its reaction on the medulla oblongata and the molecular association underlying this effect is unclear. Male wistar albino rats were separated into four groups (control, CIS, CIS+MEL, and MEL) (n = 24). CIS and CIS+MEL groups were given 4 mg/kg CIS at 4-day intervals (days 1, 5, 9, and 13) by the first day of the study. The MEL and CIS+MEL groups were given 10 mg/kg MEL daily for 13 days. At the end of the study, the medulla oblongata sections of the rats were harvested on the 14th day, and the changes in gene expressions were examined. Expression levels of inflammation markers (TNF-alpha and IL-6), apoptotic markers (Bax and Casp-3), and Aqp-1 and Aqp-4 were found to significantly increase with CIS administration. On microscopic examination, hemorrhage, edema, and perivascular edema were detected in the CIS applied group compared with controls. MEL treatment significantly reduced perivascular edema (p = 0.0152) and hemorrhage (p = 0.0087). Besides, there was a significant difference between the control and CIS groups regarding pyknosis and a significant increase in pyknotic neurons in the CIS treatment group (p < 0.001). This study indicates that CIS treatment significantly impaired medulla oblongata, and combined treatment with MEL ameliorates the injury in rats.
dc.description.sponsorship[2021/09-03]
dc.description.sponsorshipThis study did not receive any sort of financial assistance and was approved by the Animal Ethics Board of Canakkale Onsekiz Mart University (Turkey) with the decision number of 2021/09-03. I would like to thank Dr. Ihsan Karaboga for providing histopathological analysis support.
dc.identifier.doi10.55730/1300-0152.2583
dc.identifier.endpage172
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue2
dc.identifier.pmid37533514
dc.identifier.scopus2-s2.0-85129124973
dc.identifier.scopusqualityQ1
dc.identifier.startpage162
dc.identifier.trdizinid521724
dc.identifier.urihttps://doi.org/10.55730/1300-0152.2583
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/521724
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27688
dc.identifier.volume46
dc.identifier.wosWOS:000783708700005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectaquaporin-1
dc.subjectaquaporin-4
dc.subjectcisplatin
dc.subjectmedulla oblongata
dc.subjectmelatonin
dc.subjectneuroprotection
dc.titleMelatonin ameliorates cisplatin-induced neurodegeneration in medulla oblongata through the expressions of Aqp-1,-4, inflammation, and apoptosis pathway genes
dc.typeArticle

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