A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles
| dc.authorid | 0000-0002-3524-0675 | en_US |
| dc.authorid | 0000-0003-0120-530X | en_US |
| dc.authorscopusid | 57210429765 | en_US |
| dc.authorscopusid | 6602001525 | en_US |
| dc.authorwosid | --- | en_US |
| dc.authorwosid | --- | en_US |
| dc.contributor.author | Sağbaş Suner, Selin | |
| dc.contributor.author | Mohapatra, Subhra | |
| dc.contributor.author | Ayyala, Ramesh S. | |
| dc.contributor.author | Brethanabotla, Venkat R. | |
| dc.contributor.author | Şahiner, Nurettin | |
| dc.date.accessioned | 2022-04-28T13:39:09Z | |
| dc.date.available | 2022-04-28T13:39:09Z | |
| dc.date.issued | 2021 | en_US |
| dc.department | Fakülteler, Fen Fakültesi, Kimya Bölümü | |
| dc.description.abstract | Catechin (CAT) was crosslinked with trimethylolpropane triglycidyl ether(TMPTGE) to obtain degradable poly(CAT) particles in a single step. Sphericalp(CAT) particles with tens of micrometer size range and an isoelectronic pointat pH 1.2 were obtained. The hydrolytic degradation of p(CAT) particles pro-vided sustainable and extended release with 264 mg/g CAT release within10 days at pH 7.4. The antioxidant capacity of 55.0 ± 0.9μg/ml gallic acidequivalent in terms of total phenol content, and 0.88 ± 0.3μmol/g trolox equiv-alent were estimated for p(CAT) particles displaying strong radical scavengingcapability. Blood clotting and hemolysis assays demonstrated dose-dependentblood compatibility revealing higher blood compatibility for p(CAT) particlesup to 10μg/ml concentration. The cytotoxicity results show that p(CAT) parti-cles have almost no toxicity for CCD841 normal colon cells at 250μg/ml con-centration in 24 h incubation time giving ~97% cell viability, whereas CATmolecules only provide ~34% cell viability | en_US |
| dc.identifier.citation | Suner, S. S., Mohapatra, S., Ayyala, R. S., Brethanabotla, V. R., & Sahiner, N. (2021). A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles. Journal of Applied Polymer Science, 138(24), 50576. https://doi.org/10.1002/app.50576 | en_US |
| dc.identifier.doi | 10.1002/app.50576 | |
| dc.identifier.endpage | 11 | en_US |
| dc.identifier.issn | 0021-8995 | |
| dc.identifier.issn | 1097-4628 | |
| dc.identifier.issue | 24 | en_US |
| dc.identifier.scopus | 2-s2.0-85100816746 | |
| dc.identifier.startpage | 1 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12428/3558 | |
| dc.identifier.volume | 138 | en_US |
| dc.identifier.wos | WOS:000616050800001 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.institutionauthor | Sağbaş Suner, Selin | |
| dc.institutionauthor | Şahiner, Nurettin | |
| dc.language.iso | en | |
| dc.publisher | Wiley | en_US |
| dc.relation.ispartof | Journal of Applied Polymer Science | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SOBAG/1059B191801146 | |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Biodegradable | en_US |
| dc.subject | Biomaterials | en_US |
| dc.subject | Biopolymers | en_US |
| dc.subject | Catechin | en_US |
| dc.subject | Renewable polymers | en_US |
| dc.title | A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles | |
| dc.type | Article |
