A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Catechin (CAT) was crosslinked with trimethylolpropane triglycidyl ether(TMPTGE) to obtain degradable poly(CAT) particles in a single step. Sphericalp(CAT) particles with tens of micrometer size range and an isoelectronic pointat pH 1.2 were obtained. The hydrolytic degradation of p(CAT) particles pro-vided sustainable and extended release with 264 mg/g CAT release within10 days at pH 7.4. The antioxidant capacity of 55.0 ± 0.9μg/ml gallic acidequivalent in terms of total phenol content, and 0.88 ± 0.3μmol/g trolox equiv-alent were estimated for p(CAT) particles displaying strong radical scavengingcapability. Blood clotting and hemolysis assays demonstrated dose-dependentblood compatibility revealing higher blood compatibility for p(CAT) particlesup to 10μg/ml concentration. The cytotoxicity results show that p(CAT) parti-cles have almost no toxicity for CCD841 normal colon cells at 250μg/ml con-centration in 24 h incubation time giving ~97% cell viability, whereas CATmolecules only provide ~34% cell viability
Açıklama
Anahtar Kelimeler
Biodegradable, Biomaterials, Biopolymers, Catechin, Renewable polymers
Kaynak
Journal of Applied Polymer Science
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
138
Sayı
24
Künye
Suner, S. S., Mohapatra, S., Ayyala, R. S., Brethanabotla, V. R., & Sahiner, N. (2021). A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles. Journal of Applied Polymer Science, 138(24), 50576. https://doi.org/10.1002/app.50576
