Methyl donor supplementation alters serum leptin levels and increases appetite but not body weight in cross-fostered male Syrian hamster offspring (Mesocricetus auratus)

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dc.authorid0000-0003-0497-8287en_US
dc.authorscopusid13605209600en_US
dc.authorwosid-en_US
dc.contributor.authorGündüz, Bülent
dc.contributor.authorOkimoto, Darren K.
dc.date.accessioned2023-04-18T08:19:58Z
dc.date.available2023-04-18T08:19:58Z
dc.date.issued2022en_US
dc.departmentFakülteler, Fen Fakültesi, Biyoloji Bölümü
dc.description.abstractA pregnant hamster's exposure to changes in environmental factors, such as light, temperature and nutrition, may influence behavioural and physiological changes in offspring. In this study, dietary methyl donor supplementation was employed to examine the role of maternal diet on appetite, body weight, serum leptin levels and locomotor activity in male Syrian hamster offspring. Dams were fed a standard control (SC) or methyl donor-supplemented (MDSD) diet through pregnancy and lactation. At birth, offspring were cross-fostered to dams fed an SC or MDSD diet (SC-MDSD and MDSD-SC) or remained with their birth mothers (SC-SC and MDSD-MDSD). At weaning, offspring were fed a SC or MDSD diet until 60 days of age. Food intake, serum leptin levels and locomotor activity were measured from 30-60 days of age. Offspring fed a MDSD diet post-weaning (MDSD-MDSD and SC-MDSD) consumed more than double the amount of food daily compared with offspring fed a SC diet post-weaning (SC-SC, MDSD-SC). Interestingly, there were no observed differences in body weight among all four groups. Serum leptin levels at 60 days of age were depressed in offspring fed a MDSD diet post-weaning (MDSD-MDSD and SC-MDSD). There were no observed differences in wheel running activity between the SC-SC and MDSC-SC groups. Wheel running activity was at least twice the amount in offspring fed a MDSD diet post-weaning (SC-MDSD and MDSD-MDSD). Taken together, these results indicate that the timing of methyl donor supplementation appears to be an important factor during the development of offspring.en_US
dc.identifier.citationGündüz, B., & Okimoto, D. K. (2022). Methyl donor supplementation alters serum leptin levels and increases appetite but not body weight in cross‐fostered male Syrian hamster offspring ( Mesocricetus auratus ). Journal of Animal Physiology and Animal Nutrition, 106(5), 1130–1138. https://doi.org/10.1111/jpn.13665en_US
dc.identifier.doi10.1111/jpn.13665
dc.identifier.endpage1138en_US
dc.identifier.issn0931-2439
dc.identifier.issn1439-0396
dc.identifier.issue5en_US
dc.identifier.pmid34865266
dc.identifier.scopus2-s2.0-85120482066
dc.identifier.startpage1130en_US
dc.identifier.urihttps://doi.org/10.1111/jpn.13665
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4028
dc.identifier.volume106en_US
dc.identifier.wosWOS:000726343900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGündüz, Bülent
dc.language.isoen
dc.publisherWiley-VCH GmbHen_US
dc.relation.ispartofJournal of Animal Physiology and Animal Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHamsteren_US
dc.subjectLeptinen_US
dc.subjectMethyl Donor Supplementationen_US
dc.subjectMaternal Transferen_US
dc.titleMethyl donor supplementation alters serum leptin levels and increases appetite but not body weight in cross-fostered male Syrian hamster offspring (Mesocricetus auratus)
dc.typeArticle

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