Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice

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dc.authoridUner, Aykut/0000-0002-9242-8279
dc.authoridSALMANOGLU, BERRIN/0000-0003-4344-5782
dc.authoridinal, volkan/0000-0003-2649-104X
dc.authoridKOSOVA, FUNDA/0000-0001-8070-5067
dc.authoridMeral, Ogunc/0000-0001-8813-4991
dc.contributor.authorKismali, Gorkem
dc.contributor.authorUner, Aykut Gokturk
dc.contributor.authorMeral, Ogunc
dc.contributor.authorAlpay, Merve
dc.contributor.authorSalmanoglu, Berrin
dc.contributor.authorUlker Cakir, Dilek
dc.contributor.authorKosova, Funda
dc.date.accessioned2025-01-27T20:22:25Z
dc.date.available2025-01-27T20:22:25Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNatural products and anti-inflammatory agents including cyclooxygenase-2 (COX-2) inhibitors which is a type of nonsteroidal anti-inflammatory drugs (NSAIDs) are highly considerable interest for the prevention of carcinogenesis. The objective of this study is to evaluate the oxidative status of colitis-associated cancer induced by azoxymethane (AOM)/dextran sulfate sodium (DSS), and the effects of COX-2 inhibitor in mice. Totally 40 mice were randomized and divided to four groups. All animals except control and Cox-2 inhibitor alone group received AOM/DSS to establish colitis-associated cancer model as reported elsewhere. COX-2 preferential inhibitor meloxicam was used to minimize side effects such as gastrointestinal hemorrhage. Meloxicam were used (5mg/kg, intraperitoneal) three times a week with meloxicam alone and AOM/DSS + meloxicam group. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Malondialdehyde (MDA) and Advanced Oxidation Protein Products (AOPP) which all of them are oxidative stress markers were measured by spectrophotometrically. The combination treatment of Meloxicam and AOM/DSS significantly increased (P<0.05) SOD activities in mice. GPx activities were found significantly increased (P<0.05) in Meloxicam and AOM/DSS combinations or alone. There were no differences between the control and treatment groups of MDA levels. AOPP levels of Meloxicam and AOM/DSS combination group were found higher than the other groups. Meloxicam and /or AOM/DSS treatment not caused lipid peroxidations, but increased the antioxidant enzymes and Advanced Oxidation Protein Products levels.
dc.identifier.doi10.33988/auvfd.521040
dc.identifier.endpage356
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85077603455
dc.identifier.scopusqualityQ3
dc.identifier.startpage351
dc.identifier.trdizinid315312
dc.identifier.urihttps://doi.org/10.33988/auvfd.521040
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/315312
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21881
dc.identifier.volume66
dc.identifier.wosWOS:000484847800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ Press
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAzoxymethane
dc.subjectcolon cancer
dc.subjectCOX-2
dc.subjectdextran sulfate sodium
dc.subjectoxidative stress
dc.titleOxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice
dc.title.alternativeFarelerde azoksimetan/dekstran sülfat sodyum ile oluşturulan kolit ile ilişkili kanser modelinde oksidatif durum ve COX-2 inhibitörünün etkileri
dc.typeArticle

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