A multifaceted assessment of strigolactone GR24 and its derivatives: from anticancer and antidiabetic activities to antioxidant capacity and beyond

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dc.authoridBukowska, Bozena/0000-0003-3044-2953
dc.authoridKrokosz, Anita/0000-0002-1008-0548
dc.authoridPyrzanowska, Agata/0000-0002-7819-3151
dc.contributor.authorPyrzanowska-Banasiak, Agata
dc.contributor.authorTumer, Tugba Boyunegmez
dc.contributor.authorBukowska, Bozena
dc.contributor.authorKrokosz, Anita
dc.date.accessioned2025-01-27T20:12:16Z
dc.date.available2025-01-27T20:12:16Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Strigolactones are signaling molecules produced by plants, the main functions are the intracorporeal control of plant development and plant growth. GR24 strigolactone is one of the synthetic strigolactones and due to its universality and easy availability, it is a standard and model compound for research on the properties and role of strigolactones in human health.Purpose: In this research work, the impact of mainly GR24 strigolactone on the human body and the role of this strigol-type lactone in many processes that take place within the human body are reviewed.Study design: The article is a review of publications on the use of GR24 strigolactone in studies from 2010-2023. Publications were searched using PubMed, Elsevier, Frontiers, and Springer databases. The Google Scholar search engine was also used. For the review original research papers and reviews related to the presented topic were selected.Results: The promising properties of GR24 and other strigolactone analogs in anti-cancer therapy are presented. Tumor development is associated with increased angiogenesis. Strigolactones have been shown to inhibit angiogenesis, which may enhance the anticancer effect of these gamma-lactones. Furthermore, it has been shown that strigolactones have anti-inflammatory and antioxidant properties. There are also a few reports which show that the strigolactone analog may have antimicrobial and antiviral activity against human pathogens.Conclusion: When all of this is considered, strigolactones are molecules whose versatile action is their undeniable advantage. The development of research on these phytohormones makes it possible to discover their new, unique properties and surprising biological activities in relation to many mammalian cells.
dc.description.sponsorshipThe presented review was supported by the University of Lodz (IDUB, Grant No. B2311009000165.07). [B2311009000165.07]; University of Lodz
dc.description.sponsorshipThe presented review was supported by the University of Lodz (IDUB, Grant No. B2311009000165.07).
dc.identifier.doi10.3389/fmolb.2023.1242935
dc.identifier.issn2296-889X
dc.identifier.pmid37954978
dc.identifier.scopus2-s2.0-85176288976
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fmolb.2023.1242935
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20894
dc.identifier.volume10
dc.identifier.wosWOS:001099560800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Molecular Biosciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectstrigolactones
dc.subjectGR24
dc.subjectmammalian cells
dc.subjectantioxidants
dc.subjectantiangiogenic activity
dc.subjectcancer
dc.titleA multifaceted assessment of strigolactone GR24 and its derivatives: from anticancer and antidiabetic activities to antioxidant capacity and beyond
dc.typeReview Article

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