In Vitro Evaluation of Biofilm Forming Capacity and Antifungal Resistance of Yeast Isolated from Individuals Aged 18-25 Years

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dc.contributor.authorAteş, Gülçin Özcan
dc.contributor.authorOtkun, Müşerref Tatman
dc.date.accessioned2025-01-27T19:32:56Z
dc.date.available2025-01-27T19:32:56Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMicrobiota studies are an increasingly important issue today. In the literature, there are limited studies on the antifungal resistance and biofilm formation capacity of yeasts isolated from the mouths of young individuals. For this reason, our study was carried out with 133 yeast isolates isolated from the mouths of 17 young individuals between the ages of 18-25 in 2018-2020. When the biofilm-forming capacities of 133 isolates were examined, it was determined that 99.25% were biofilm producers by tissue culture plate method and 66.92% by tube method. One hundred thirty-three yeast isolates and seven reference strains were first evaluated against fluconazole antifungal by agar disc diffusion method. The isolates were found to be susceptible to fluconazole. According to this result, 20 isolates with strong biofilm-forming capacity were selected from 133 yeast isolates. Antifungal resistance was evaluated with fluconazole, itraconazole, clotrimazole, amphotericin B and nystatin gradient test strips. It was determined that 20 isolates were resistant to amphotericin B, and 18 were resistant to nystatin antifungal. It was determined that the sensitivity of itraconazole to 14 isolates and clotrimazole to 3 isolates was dose-dependent. As a result, azole group antifungals can be used mainly in treating oral yeast infections.
dc.identifier.doi10.33484/sinopfbd.1310745
dc.identifier.endpage18
dc.identifier.issn2536-4383
dc.identifier.issn2564-7873
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid1191808
dc.identifier.urihttps://doi.org/10.33484/sinopfbd.1310745
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1191808
dc.identifier.urihttps://hdl.handle.net/20.500.12428/16517
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSinop Üniversitesi fen bilimleri dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectMikrobiyoloji
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectHücre Biyolojisi
dc.titleIn Vitro Evaluation of Biofilm Forming Capacity and Antifungal Resistance of Yeast Isolated from Individuals Aged 18-25 Years
dc.typeArticle

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