Enhanced Bioactive Properties of Halloysite Nanotubes via Polydopamine Coating

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dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorDemirci, Şahin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:14:17Z
dc.date.available2025-01-27T20:14:17Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHalloysite nanotubes (HNT) were coated five times with dopamine (DOPA) in a tris buffer medium at pH 8.5 to acquire polydopamine-coated HNTs (PDOPA@HNT), e.g., PDOPA1@HNT, PDOPA3@HNT, and PDOPA5@HNT. Upon coating HNT with PDOPA, the surface area, pore volume, and pore size were decreased depending on the number of coatings. While the surface area of HNT was 57.9 m(2)/g, by increasing the number of coatings from 1 to 5, it was measured as 55.9, 53.4, 53.3, 47.4, and 46.4 m(2)/g, respectively. The isoelectric point (IEP) for HNTs was determined as 4.68, whereas these values are estimated as 2.31 for PDOPA1@HNTs, 3.49 for PDOPA3@HNT, and 3.55 for PDOPA5@HNT. Three different antioxidant studies were conducted for HNT and PDOPA@HNT, and the total phenol (TPC) value of HNT was found to be 150.5 +/- 45.9 mu mol gallic acid (GA) equivalent. The TPC values for PDOPA1@HNT, PDOPA3@HNT and PDOPA5@HNT coatings were found to be 405.5 +/- 25.0, 750.0 +/- 69.9, and 1348.3 +/- 371.7 mu mol GA equivalents, respectively. The Fe(II) chelation capacity of HNT was found to be 20.5% +/- 1.2%, while the PDOPA1@HNT, PDOPA3@HNT and PDOPA5@HNT values were found to be 49.9 +/- 6.5, 36.6 +/- 12.7 and 25.4 +/- 1.2%, respectively. HNT and PDOPA@HNTs inhibited the alpha-glucosidase (AG) enzyme to greater extents than acetylcholinesterase (AChE). As a result, the DOPA modification of HNTs was rendered to provide additional characteristics, e.g., antioxidant properties and higher AChE and AG enzymes inhibition capabilities. Therefore, PDOPA@HNTs have great potential as biomaterials.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit [FBA-2021-3631]
dc.description.sponsorshipThis research was funded by the Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit with project number FBA-2021-3631.
dc.identifier.doi10.3390/polym14204346
dc.identifier.issn2073-4360
dc.identifier.issue20
dc.identifier.pmid36297924
dc.identifier.scopus2-s2.0-85140893030
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym14204346
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21030
dc.identifier.volume14
dc.identifier.wosWOS:000873647400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPolymers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjecthalloysite nanotube composite
dc.subjectpolydopamine coating
dc.subjectantioxidant natural clay
dc.subjectblood compatible
dc.subjectsurface modified HNT with PDOPA
dc.titleEnhanced Bioactive Properties of Halloysite Nanotubes via Polydopamine Coating
dc.typeArticle

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