Carboxymethyl Chitosan Microgels for Sustained Delivery of Vancomycin and Long-Lasting Antibacterial Effects

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dc.authoridYılmaz, Aynur Sanem / 0000-0002-5260-7678
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorYılmaz, Aynur Sanem
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:39:26Z
dc.date.available2025-01-27T20:39:26Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.descriptionThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractCarboxymethyl chitosan (CMCh) is a unique polysaccharide with functional groups that can develop positive and negative charges due to the abundant numbers of amine and carboxylic acid groups. CMCh is widely used in different areas due to its excellent biocompatibility, biodegradability, water solubility, and chelating ability. CMCh microgels were synthesized in a microemulsion environment using divinyl sulfone (DVS) as a crosslinking agent. CMCh microgel with tailored size and zeta potential values were obtained in a single stem by crosslinking CMCh in a water-in-oil environment. The spherical microgel structure is confirmed by SEM analysis. The sizes of CMCh microgels varied from one micrometer to tens of micrometers. The isoelectric point of CMCh microgels was determined as pH 4.4. Biocompatibility of CMCh microgels was verified on L929 fibroblasts with 96.5 & PLUSMN; 1.5% cell viability at 1 mg/mL concentration. The drug-carrying abilities of CMCh microgels were evaluated by loading Vancomycin (Van) antibiotic as a model drug. Furthermore, the antibacterial activity efficiency of Van-loaded CMCh microgels (Van@CMCh) was investigated. The MIC values of the released drug from Van@CMCh microgels were found to be 68.6 and 7.95 & mu;g/mL against E. coli and S. aureus, respectively, at 24 h contact time. Disk diffusion tests confirmed that Van@CMCh microgels, especially for Gram-positive (S. aureus) bacteria, revealed long-lasting inhibitory effects on bacteria growth up to 72 h.
dc.description.sponsorshipOphthalmology Department at USF
dc.description.sponsorshipSome parts of this work were supported by the startup funds (N. Sahiner) from the Ophthalmology Department at USF.
dc.identifier.doi10.3390/gels9090708
dc.identifier.issn2310-2861
dc.identifier.issue9
dc.identifier.pmid37754390
dc.identifier.scopus2-s2.0-85172189900
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/gels9090708
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23947
dc.identifier.volume9
dc.identifier.wosWOS:001073981300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofGels
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectcarboxymethyl chitosan
dc.subjectmicrogel
dc.subjectsustained drug delivery
dc.subjectantibiotic
dc.subjectFe (II) chelating activity
dc.subjectvancomycin
dc.subjectprolonged antibacterial effect
dc.titleCarboxymethyl Chitosan Microgels for Sustained Delivery of Vancomycin and Long-Lasting Antibacterial Effects
dc.typeArticle

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