A comprehensive investigation of PtNPs/PEI N-GQDs nanocomposite: DFT modeling, anticancer activity, and biosensing applications

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dc.authoridKabaş, Sultan Yagmur / 0000-0002-2329-2451
dc.authoridKaya, İsmet / 0000-0002-9813-2962
dc.authoridYıldız, Mustafa / 0000-0001-5833-7499
dc.contributor.authorAltınok Güneş, Buket
dc.contributor.authorKırlangıç, Ömer Faruk
dc.contributor.authorKılıç, Murat
dc.contributor.authorKetenoğlu, Didem
dc.contributor.authorAslan, Ayşenur
dc.contributor.authorKabaş, Sultan Yağmur
dc.contributor.authorKabaş, Afşar
dc.contributor.authorKaya, İsmet
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2025-05-29T02:58:04Z
dc.date.available2025-05-29T02:58:04Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis research focuses on the synthesis and characterization of a novel nanocomposite, PtNPs/PEI N-GQDs, utilizing FTIR, UV-Vis, SEM, TEM, XPS, and XRD techniques. The study investigates the cytotoxic, apoptotic, and antiangiogenic effects of the nanocomposite on OVCAR-3 cells, aiming to understand the interplay between nanomaterials and cancer. Additionally, the electrochemical properties of PtNPs/PEI N-GQDs-modified glassy carbon electrodes (GCE) are explored, emphasizing analyses of HOMO-LUMO energy levels and band gap energy. Density Functional Theory (DFT) analysis results further support these findings by providing insights into the electronic structure and energetics of the nanocomposite. The nanocomposite exhibits promising electrochemical behavior, demonstrating high capacitance and sensitivity in glucose detection through cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Selectivity towards glucose among interfering bioanalytes is highlighted, showcasing potential applications in tumor monitoring and diagnosis. Furthermore, the nanocomposite displays significant toxicity against cancer cells, inducing apoptosis and cell cycle arrest. Antiangiogenic effects are also observed, suggesting potential therapeutic benefits. Overall, these findings underscore the multifunctional properties of the synthesized nanocomposite, offering insights into its potential for cancer therapy and biosensor applications for glucose detection in bodily fluids.
dc.description.sponsorshipAnkara Universitesi [FBA-2024-3174]; Ankara University Scientific Research Projects Coordination Unit
dc.description.sponsorshipThis work was supported by Ankara University Scientific Research Projects Coordination Unit (Grant number: FBA-2024-3174). The numerical calculations reported in this paper were fully performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources). XPS and TEM analyses were performed at METU Central Laboratory.
dc.identifier.doi10.1007/s10853-025-10722-y
dc.identifier.endpage4278
dc.identifier.issn0022-2461
dc.identifier.issn1573-4803
dc.identifier.issue9
dc.identifier.scopus2-s2.0-85219210655
dc.identifier.scopusqualityQ1
dc.identifier.startpage4258
dc.identifier.urihttps://doi.org/10.1007/s10853-025-10722-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30266
dc.identifier.volume60
dc.identifier.wosWOS:001431833000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Materials Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectGraphene Quantum Dots
dc.subjectCell-Cycle Arrest
dc.subjectDna Fragmentation
dc.subjectInduce Apoptosis
dc.subjectPhotoluminescence
dc.subjectCytotoxicity
dc.subjectHallmark
dc.subjectGreen
dc.subjectHomo
dc.subjectLumo
dc.titleA comprehensive investigation of PtNPs/PEI N-GQDs nanocomposite: DFT modeling, anticancer activity, and biosensing applications
dc.typeArticle

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