Relationship between oxytocin receptor gene polymorphism and hypertension in Turkish population

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dc.authoridHIZ, Meliha Merve/0000-0003-4303-9717
dc.contributor.authorCicekliyurt, Merve M.
dc.contributor.authorDermenci, Begum
dc.date.accessioned2025-01-27T20:34:55Z
dc.date.available2025-01-27T20:34:55Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction and objectives: Known to play a key role in uterine contraction and milk ejec-tion, the neuropeptide, oxytocin, has cardiovascular effects. To date, the known cardiovascular effects of oxytocin are blood pressure lowering (caused by natriuresis and atrial natriuretic peptide release), negative inotropic and chronotropic effect caused by parasympathetic neu-romodulation, anti-stress effect and vasodilation mediated by activation of the nitric oxide pathway. The clinical significance of the rs2268498 polymorphism in oxytocin receptors in these effects is controversial. Based on the known genetic inheritance of hypertension, our research aimed to determine whether the presence of the rs2268498 oxytocin receptor (OXTR) allele C affects hypertension in our region. Methods: This article is a case-control study conducted in the Turkish population. About 140 normotensive and 140 isolated hypertensive volunteers included in the research and genotyped with real-time PCR hybridization method via melt curve analysis.Results: Oxytocin receptor rs2268498 polymorphism was assessed in terms of the risk of hyper-tension and hypertensive individuals were compared to the control group. OXTR rs2268498 polymorphism was not found to be a significant risk factor for dominant, recessive and addi-tive modeled hypertension (ORdominant: 0.966, 95% CI: 0.57-1.61, p: 0.9; ORrecessive: 1, 95% CI: 0.58-1.71, p: 1.0 and ORoverall: 0.98, chi2=0.01).Conclusion: We concluded that rs2268498 single nucleotide polymorphism is not a risk factor for hypertension in our region.(c) 2022 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espan tilde a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.identifier.doi10.1016/j.repc.2021.06.028
dc.identifier.endpage916
dc.identifier.issn0870-2551
dc.identifier.issn0304-4750
dc.identifier.issue11
dc.identifier.pmid36266116
dc.identifier.scopus2-s2.0-85148942954
dc.identifier.scopusqualityQ3
dc.identifier.startpage911
dc.identifier.urihttps://doi.org/10.1016/j.repc.2021.06.028
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23516
dc.identifier.volume41
dc.identifier.wosWOS:000878592200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Espana Slu
dc.relation.ispartofRevista Portuguesa De Cardiologia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectOxytocin
dc.subjectEssential hypertension
dc.subjectVascular diseases
dc.titleRelationship between oxytocin receptor gene polymorphism and hypertension in Turkish population
dc.title.alternativeRelação entre o polimorfismo do gene recetor da ocitocina e a hipertensão na população turca
dc.typeArticle

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