Relationship between oxytocin receptor gene polymorphism and hypertension in Turkish population
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Espana Slu
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction and objectives: Known to play a key role in uterine contraction and milk ejec-tion, the neuropeptide, oxytocin, has cardiovascular effects. To date, the known cardiovascular effects of oxytocin are blood pressure lowering (caused by natriuresis and atrial natriuretic peptide release), negative inotropic and chronotropic effect caused by parasympathetic neu-romodulation, anti-stress effect and vasodilation mediated by activation of the nitric oxide pathway. The clinical significance of the rs2268498 polymorphism in oxytocin receptors in these effects is controversial. Based on the known genetic inheritance of hypertension, our research aimed to determine whether the presence of the rs2268498 oxytocin receptor (OXTR) allele C affects hypertension in our region. Methods: This article is a case-control study conducted in the Turkish population. About 140 normotensive and 140 isolated hypertensive volunteers included in the research and genotyped with real-time PCR hybridization method via melt curve analysis.Results: Oxytocin receptor rs2268498 polymorphism was assessed in terms of the risk of hyper-tension and hypertensive individuals were compared to the control group. OXTR rs2268498 polymorphism was not found to be a significant risk factor for dominant, recessive and addi-tive modeled hypertension (ORdominant: 0.966, 95% CI: 0.57-1.61, p: 0.9; ORrecessive: 1, 95% CI: 0.58-1.71, p: 1.0 and ORoverall: 0.98, chi2=0.01).Conclusion: We concluded that rs2268498 single nucleotide polymorphism is not a risk factor for hypertension in our region.(c) 2022 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espan tilde a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Açıklama
Anahtar Kelimeler
Oxytocin, Essential hypertension, Vascular diseases
Kaynak
Revista Portuguesa De Cardiologia
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
41
Sayı
11
