Investigation of the Relationship between Inflammation and Oxidative Stress Markers and Treatment Response in First-Attack Major Depression Patients: A Follow-Up Study

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dc.contributor.authorEmekdar, Gizem
dc.contributor.authorTas, Halil Ibrahim
dc.contributor.authorSehitoglu, Hilal
dc.date.accessioned2025-01-27T20:14:13Z
dc.date.available2025-01-27T20:14:13Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: There is a need to biomarkers for major depression (MD). The goals of this study are to compare serum levels of oxidative stress markers malondialdehyde (MDA) and F2-isoprostane and inflammation markers tumor necrosis factor-alpha (TNF-& alpha;), interleukin-6 (IL-6) and C-reactive protein (CRP) between patients with first-episode MD and healthy controls, to investigate the change of these markers after treatment and to investigate the relationship between levels of these markers and treatment response.Method: Our study was performed in 30 first-episode MD patients and 30 healthy volunteers. During the clinical evaluation Hamilton Depression Rating Scale and Clinical Global Impression Scale were applied to the participants. Serum levels of markers were measured at the baseline and after 8 weeks of treatment.Results: Compared to the control group, first-episode MD patients had significantly higher IL-6, CRP and MDA levels and lower F2-isoprostane levels. There was no difference between the groups in terms of TNF-& alpha; levels. TNF-& alpha;, IL-6, MDA and F2-isoprostane levels decreased significantly after treatment, whereas there was no significant change in CRP levels with treatment. Baseline F2-isoprostane levels were found to be significantly higher in treatment responders than non -responders (p<0.05).Conclusion: In our study, it was shown that there are irregularities related to inflammatory processes and oxidative stress in MD, even in patients who had their first-episode and did not take medication, and these irregularities can be resolved after treatment. While there was a relationship between treatment response and baseline F2-isoprostane levels, there was no relationship with other biomarkers.
dc.identifier.doi10.5080/u26698
dc.identifier.endpage99
dc.identifier.issn1300-2163
dc.identifier.issue2
dc.identifier.pmid37357895
dc.identifier.scopus2-s2.0-85162829342
dc.identifier.scopusqualityQ3
dc.identifier.startpage89
dc.identifier.trdizinid1255533
dc.identifier.urihttps://doi.org/10.5080/u26698
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1255533
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21001
dc.identifier.volume34
dc.identifier.wosWOS:001044267800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegi
dc.relation.ispartofTurk Psikiyatri Dergisi
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBiomarkers
dc.subjectdepression
dc.subjectinflammation
dc.subjectoxidative stress
dc.subjecttreatment response
dc.titleInvestigation of the Relationship between Inflammation and Oxidative Stress Markers and Treatment Response in First-Attack Major Depression Patients: A Follow-Up Study
dc.typeArticle

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