Lipoprotein(a): A New Intensive Care Unit Admission Predictor in Coronavirus Disease 2019 Patients

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dc.authoridALKAN, Sevil/0000-0003-1944-2477
dc.contributor.authorKucuk, Ugur
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorSener, Alper
dc.contributor.authorAlkan, Sevil
dc.contributor.authorVurucu, Servan
dc.contributor.authorAksit, Ercan
dc.date.accessioned2025-01-27T21:21:15Z
dc.date.available2025-01-27T21:21:15Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOBJECTIVE: Endothelium-related events in patients with coronavirus disease 2019 are linked to a poor prognosis. Lipoprotein(a) plays a role in vascular endothelial cell dysfunction. This research aims to investigate whether baseline serum lipoprotein(a) levels could be a predictor for intensive care unit admission and related clinical parameters in coronavirus disease 2019 patients. MATERIAL AND METHODS: The research covers 126 patients who were hospitalized in intensive care unit or the non-intensive care unit in our hospital. This prospective cohort study was conducted from January 2021 to June 2021. The patients who were positive for severe acute respiratory syndrome coronavirus 2 according to real-time polymerase chain reaction test results were included in the study. Two groups were created according to the status of intensive care unit admission. Lipoprotein(a) was studied from blood samples taken at the time of hospital admission. RESULTS: According to the results of the first clinical evaluation, 46 patients were admitted to the intensive care unit and 80 patients were admitted to non-intensive care unit in the hospital. Patients with intensive care unit admission had significantly higher serum lipoprotein(a) levels than patients without intensive care unit admission (40.9 ng/mL and 17.4 ng/mL, P < .001, respectively). The regres-sion analysis revealed that serum lipoprotein(a) levels were independently related to intensive care unit admission (odds ratio 1.242, 95% CI 1.109-1.391, P < .001). In receiver operating characteristic curve analysis, lipoprotein(a) level & GE;31.42 ng/mL had 82.6% sensitivity and 72.5% specificity in predicting intensive care unit admission. The risk of intensive care unit admission was seen to be 12.522-fold higher in cases with lipoprotein(a) level & GE;31.42. CONCLUSION: Lipoprotein(a) could be used as a useful biomarker for the triage of coronavirus disease 2019 patients. Baseline serum lipoprotein(a) levels may serve as a useful prognostic biomarker in patients hospitalized for coronavirus disease 2019.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit [THD-2021-3588]
dc.description.sponsorship& nbsp;This study was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit (project number: THD-2021-3588) . The research sponsors did not participate in the study design, data collection, analysis, and interpretation; not involved in the writing of the manuscript and the decision to submit the manuscript for publication.
dc.identifier.doi10.5152/ThoracResPract.2023.22065
dc.identifier.endpage+
dc.identifier.issn2979-9139
dc.identifier.issue4
dc.identifier.pmid37485711
dc.identifier.scopus2-s2.0-85165995467
dc.identifier.scopusqualityQ4
dc.identifier.startpage214
dc.identifier.trdizinid1238783
dc.identifier.urihttps://doi.org/10.5152/ThoracResPract.2023.22065
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1238783
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28862
dc.identifier.volume24
dc.identifier.wosWOS:001048621100007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofThoracic Research and Practice
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCOVID-19
dc.subjectmortality
dc.subjectclinical outcome
dc.subjectlipoprotein(a)
dc.titleLipoprotein(a): A New Intensive Care Unit Admission Predictor in Coronavirus Disease 2019 Patients
dc.typeArticle

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