A novel approach to glioblastoma multiforme treatment using modulation of key pathways by naturally occurring small molecules

Basit Öğe Kaydı
dc.contributor.authorAfshari, Amir R.
dc.contributor.authorSanati, Mehdi
dc.contributor.authorAminyavari, Samaneh
dc.contributor.authorKeshavarzi, Zakieh
dc.contributor.authorAhmadi, Seyed Sajad
dc.contributor.authorOroojalian, Fatemeh
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-05-29T02:58:05Z
dc.date.available2025-05-29T02:58:05Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGlioblastoma multiforme (GBM), the fatal primary brain malignancy in adults, represents significant health challenges, and its eradication has been the ultimate goal of numerous medical investigations. GBM therapy encompasses various interventions, e.g., chemotherapy by synthetic cytotoxic agents like temozolomide (TMZ), radiotherapy, and, more recently, immunotherapy. A notable focus has been on incorporating naturally occurring substances in treating malignancies. Polyphenols and terpenoids, widely present in fruits and vegetables, constitute primary categories of agents employed for this purpose. They pose direct and indirect impacts on tumor growth and chemoresistance, mainly through impacting the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling, crucial in cellular processes, metabolism, and programmed death. This paper thoroughly discusses the biologic effects and practical application of polyphenols and terpenoids on GBM through the PI3K/Akt/mTOR signaling in vitro and in vivo.
dc.identifier.doi10.1007/s10787-025-01666-5
dc.identifier.issn0925-4692
dc.identifier.issn1568-5608
dc.identifier.pmid39955698
dc.identifier.scopus2-s2.0-85218180878
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10787-025-01666-5
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30269
dc.identifier.wosWOS:001422012200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Basel Ag
dc.relation.ispartofInflammopharmacology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectGlioblastoma multiforme
dc.subjectPolyphenols
dc.subjectNatural compounds
dc.subjectmTOR
dc.subjectChemoprevention
dc.titleA novel approach to glioblastoma multiforme treatment using modulation of key pathways by naturally occurring small molecules
dc.typeReview

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu