Comparison of Normal saline, Activated Charcoal and Intravenous Lipid Emulsion in a Rat Model of Colchicine Overdose: Experimental Study

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dc.authoridCanbolat, Fadime / 0000-0001-6759-7735
dc.contributor.authorÇelikmen, Mustafa Ferudun
dc.contributor.authorSarıkaya, Sezgin
dc.contributor.authorÖzüçelik, Doğaç Niyazi
dc.contributor.authorCanbolat, Fadime
dc.contributor.authorSümer, Engin
dc.contributor.authorKeleş, Elif Çiğdem
dc.contributor.authorMaktav Çelikmen, Deniz Sema
dc.date.accessioned2025-01-27T20:50:11Z
dc.date.available2025-01-27T20:50:11Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: The aim of this study is to investigate the effects of Normal Saline (NS), Activated Charcoal (AC) and Intravenous Lipid Emulsion (ILE) in colchicine poisonings that resulted in death. Study Design: The research is an experimental study carried out in a medical school animal laboratory. Materials and Methods: 24 female Sprague-Dawley rats were divided into 4 equal groups. After giving Colchicine (1 mg/kg, PO) to all animals, different treatments (NS, AC, ILE) were given to 3 groups. Group 4 was not treated. Colchicine blood samples (0.8 mL) were taken from the vena jugularis externa at 4, 8 and 24 hr and evaluated by liquid chromatography. Results: While the blood colchicine level decreased in all groups at 24 hr, the highest decrease was observed in the AC group. Compared to the 4 th hr, blood colchicine levels at 8 hr decreased by 15.49% in the NS group, 64.55% in the AC group and 34.56% in the ILE group. Blood colchicine levels at 24 hr decreased by 66.1% in the NS group, 73.12% in the AC group, 37.73% in the ILE group and 59.17% in the untreated group compared to the 8 th hr. Conclusion: AC administration is very effective in lowering blood colchicine levels. ILE can be used with NS and AC as an early treatment option for colchicine overdoses. However, further studies are needed for more effective methods in the treatment of colchicine overdose.
dc.description.sponsorshipWe respectfully commemorate our pediatrician friend, associate professor Suat Bicer, who lost due to the colchicine overdose that led to the emergence of this study.
dc.identifier.doi10.5530/ijper.58.3.87
dc.identifier.endpage801
dc.identifier.issn0019-5464
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85197879426
dc.identifier.scopusqualityQ3
dc.identifier.startpage794
dc.identifier.urihttps://doi.org/10.5530/ijper.58.3.87
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25433
dc.identifier.volume58
dc.identifier.wosWOS:001291200300010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAssoc Pharmaceutical Teachers India
dc.relation.ispartofIndian Journal of Pharmaceutical Education and Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectColchicine overdose
dc.subjectintoxication
dc.subjectNormal saline
dc.subjectActivated charcoal
dc.subjectintravenous lipid emulsion
dc.titleComparison of Normal saline, Activated Charcoal and Intravenous Lipid Emulsion in a Rat Model of Colchicine Overdose: Experimental Study
dc.typeArticle

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