Important Roles of Interleukin-36, Interleukin-37, and Interleukin-38 Cytokines in the Pathogenesis of Rosacea

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dc.contributor.authorEkinci, Alper
dc.contributor.authorKilic, Sevilay O.
dc.contributor.authorDemir, Nesrin
dc.contributor.authorSiddikoglu, Duygu
dc.date.accessioned2025-01-27T21:19:57Z
dc.date.available2025-01-27T21:19:57Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases. Aims and Objectives: The present study aims to evaluate the relationship of these cytokines with rosacea. Materials and Methods: A total of 100 individuals, including 50 patients with rosacea and 50 healthy controls, were included in the study. IL-36, IL-37, and IL-38 levels were measured using the ELISA method by taking serum samples from all participants. Results: The mean serum levels of IL-36, IL-37, and IL-38 in the patient group were 52.17 +/- 24.07 pg/ml, 18.46 +/- 8.18 pg/ml, and 25.74 +/- 8.36 ng/l, respectively. The mean serum levels of IL-36, IL-37, and IL-38 in the control group were 32.99 +/- 19.90 pg/ml, 44.61 +/- 22.27 pg/ml, and 45.61 +/- 17.32 ng/l, respectively. The difference between the serum levels of IL-36, IL-37, and IL-38 in the patient and control groups was statistically significant (P < 0.001). Conclusion: Based on these findings, an increase in IL-36 and a decrease in IL-37 and IL-38 may contribute to the pathogenesis of rosacea. Future rosacea treatments could target and/or interact with these possible steps in the pathogenesis of rosacea.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit [TTU-2020-3298]
dc.description.sponsorshipThis research was financially supported by the Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit (project code TTU-2020-3298).
dc.identifier.doi10.4103/ijd.ijd_470_23
dc.identifier.endpage237
dc.identifier.issn0019-5154
dc.identifier.issn1998-3611
dc.identifier.issue3
dc.identifier.pmid39119329
dc.identifier.scopus2-s2.0-85197577500
dc.identifier.scopusqualityQ3
dc.identifier.startpage232
dc.identifier.urihttps://doi.org/10.4103/ijd.ijd_470_23
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28779
dc.identifier.volume69
dc.identifier.wosWOS:001369780200024
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Dermatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectInflammation
dc.subjectinterleukin-36
dc.subjectinterleukin-37
dc.subjectinterleukin-38
dc.subjectrosacea
dc.titleImportant Roles of Interleukin-36, Interleukin-37, and Interleukin-38 Cytokines in the Pathogenesis of Rosacea
dc.typeArticle

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