Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats

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dc.authoridkaymaz, burak/0000-0001-6207-8063
dc.authoridoktay, murat/0000-0002-0893-4444
dc.contributor.authorKomurcu, Erkam
dc.contributor.authorOktay, Murat
dc.contributor.authorKaymaz, Burak
dc.contributor.authorHatay Golge, Umut
dc.contributor.authorGoksel, Ferdi
dc.contributor.authorNusran, Gurdal
dc.date.accessioned2025-01-27T20:23:00Z
dc.date.available2025-01-27T20:23:00Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The aim of this study was to examine the role of coenzyme Q(10) (CoQ(10)) in the prevention of steroid-induced osteonecrosis of the femoral head (ONFH) in rats. Methods: The study included 20 Sprague-Dawley rats injected once with 20 mg/kg of methylprednisolone acetate into the right gluteus medius muscle to induce osteonecrosis. Animals were divided into two equal groups; Group 1 received no prophylaxis (control group) and the Group 2 received CoQ(10). Hematological examinations were performed before steroid injection (0 weeks) and at 4 weeks after steroid injection. Femoral heads were examined histologically to evaluate osteonecrosis. Results: Changes in blood glutathione (GSH) and malondialdehyde (MDA) concentrations were less significant in the CoQ(10) group. The incidence of histologic changes consistent with early osteonecrosis was lower in the CoQ(10) group (2 of 10; 20%) than the control group (7 of 10; 70%). Conclusion: Coenzyme Q(10) may be useful as a preventing agent in steroid-induced ONFH. Inhibited oxidative stress is a possible mechanism for this effect.
dc.identifier.doi10.3944/AOTT.2014.13.0150
dc.identifier.endpage222
dc.identifier.issn1017-995X
dc.identifier.issue2
dc.identifier.pmid24747633
dc.identifier.scopus2-s2.0-84899641822
dc.identifier.scopusqualityQ2
dc.identifier.startpage217
dc.identifier.trdizinid158650
dc.identifier.urihttps://doi.org/10.3944/AOTT.2014.13.0150
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/158650
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22095
dc.identifier.volume48
dc.identifier.wosWOS:000335199800019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Orthopaedics Traumatology
dc.relation.ispartofActa Orthopaedica Et Traumatologica Turcica
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCoenzyme Q(10)
dc.subjectglutathione
dc.subjectmalondialdehyde
dc.subjectsteroid-induced osteonecrosis
dc.titlePreventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats
dc.typeArticle

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