Antibacterial and Antibiofilm Activities of Ceragenins Alone and in Combination with Levofloxacin Against Multidrug Resistant Myroides spp. Clinical Isolates from Patients with Urinary Tract Infections

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dc.authorid0000-0002-1419-2088en_US
dc.authorid0000-0003-0325-886Xen_US
dc.authorscopusid58263193000en_US
dc.authorscopusid24921413500en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorOyardi, Özlem
dc.contributor.authorEltimur, Tuba
dc.contributor.authorDemir, Elif Sena
dc.contributor.authorAlkan, Busra
dc.contributor.authorSavage, Paul B. B.
dc.contributor.authorAlper Akçalı
dc.contributor.authorBozkurt-Güzel, Çağla
dc.date.accessioned2023-08-21T08:12:10Z
dc.date.available2023-08-21T08:12:10Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractMyroides spp. are rare opportunistic pathogens, but they can be life-threatening because of their multidrug-resistant drug properties and their potential to cause outbreaks, especially in immunosuppressed patients. In this study, 33 isolates isolated from intensive care patients with urinary tract infections were examined for drug susceptibility. All isolates except three proved to be resistant to the tested conventional antibiotics. The effects of ceragenins, a class of compounds developed to mimic endogenous antimicrobial peptides, were evaluated against these organisms. The MIC values of nine ceragenins were determined, and the most effective ceragenins were CSA-131 and CSA-138. Three isolates that were susceptible to levofloxacin and two isolates resistant to all antibiotics underwent 16 s rDNA analysis, and whereas resistant isolates were identified as M. odoratus, susceptible isolates were identified as M. odoratimimus. CSA-131 and CSA-138 showed rapid antimicrobial effects observed in time-kill analyses. Combinations of ceragenins and levofloxacin caused a significant increase in antimicrobial and antibiofilm activities against M. odoratimimus isolates. In this study, Myroides spp. were found to be multidrug-resistant and have biofilm forming capacity, and ceragenins CSA-131 and CSA-138 were found to be especially effective on both planktonic and biofilm forms of Myroides spp.en_US
dc.identifier.citationOyardi, O., Eltimur, T., Demir, E. S., Alkan, B., Savage, P. B., Akçalı, A., & Bozkurt-Güzel, C. (2023). Antibacterial and Antibiofilm Activities of Ceragenins Alone and in Combination with Levofloxacin Against Multidrug Resistant Myroides spp. Clinical Isolates from Patients with Urinary Tract Infections. Current Microbiology, 80(6), 1–12. https://doi.org/10.1007/s00284-023-03321-0en_US
dc.identifier.doi10.1007/s00284-023-03321-0
dc.identifier.issn0343-8651
dc.identifier.issn1432-0991
dc.identifier.issue6en_US
dc.identifier.pmid37191731
dc.identifier.scopus2-s2.0-85159738519
dc.identifier.urihttps://doi.org/10.1007/s00284-023-03321-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4500
dc.identifier.volume80en_US
dc.identifier.wosWOS:000991966800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEltimur, Tuba
dc.institutionauthorAkçalı, Alper
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofCurrent Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectAnti-Infective Agentsen_US
dc.subjectBiofilmsen_US
dc.subjectFlavobacteriaceaeen_US
dc.subjectHumansen_US
dc.subjectLevofloxacinen_US
dc.subjectMicrobial Sensitivity Testsen_US
dc.subjectUrinary Tract Infectionsen_US
dc.titleAntibacterial and Antibiofilm Activities of Ceragenins Alone and in Combination with Levofloxacin Against Multidrug Resistant Myroides spp. Clinical Isolates from Patients with Urinary Tract Infections
dc.typeArticle

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