Bio-MOFs Based on Natural Phenolic, Hematoxylin Leverages Biomedical Applications: Enzyme Inhibition, Antioxidant, and Antibacterial Properties

Basit Öğe Kaydı
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorTian, Zhi
dc.contributor.authorDemirci, Şahin
dc.contributor.authorSunol, Aydın
dc.contributor.authorAllen-Gipson, Diane S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:45:28Z
dc.date.available2025-01-27T20:45:28Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHere, using natural hematoxylin (HT) as linker, metal-organic frameworks (MOFs) from Cu(II), Fe(II), and Fe(III) ions was prepared. The SEM images and DLS analyses revealed HT-based MOFs are <micrometer sizes with the highest surface area value of 49.2 m2/g for HT−Fe(III) MOFs. Interestingly, HT-based MOFs exhibit fluorescent properties at λem=330 nm with fluorescence intensities of 11485, 2120, and 6790 (a.u) for HT−Cu(II), Fe(II), and Fe(III) MOFs, respectively. Moreover, HT-based MOFs inhibited α-glucosidase enyzme in a concentration-dependent manner e. g., 33.1 %, 69.8 %, and 59.7 % of Cenzyme=500 mg/mL was inhibited by HT−Cu(II)-MOF, HT−Fe(II)-MOF, and HT−Fe(III)-MOFs, respectively. The minimum bactericidal concentration (MBC) values of HT−Cu(II) MOFs for Escherichia coli (gram −), Staphylococcus aureus (gram +), and Candida albicans are determined as 5, 5, and 10 mg/mL, respectively. Also, the antioxidant activities of 250 ppm HT-based MOF based on total phenol content (TPC) tests revealed 279, 208, 124, and 152 mg.gallic acid equivalent/mL (mg GA equivalency/mL) for HT, HT−Cu(II) MOF, HT−Fe(II) MOF, and HT−Fe(III), respectively affirming that antioxidant properties were retained. Moreover, HT−Fe(II) and HT−Fe(III) MOFs (62.5 μg/mL) against human null-1 lung cell line revealed cell viabilities of 98.7±12.2 % and 88.9±11.7 %, respectively as concentration-dependent biocompatibility of MOFs.
dc.description.sponsorshipBIdot;DEB-2219 Postdoctoral Research Program [1059B192201458]; Scientific and Technological Research Council of Turkey (TUBITAK)
dc.description.sponsorshipThe B & Idot;DEB-2219 Postdoctoral Research Program, 1059B192201458, of the Scientific and Technological Research Council of Turkey (TUBITAK) provided funding for this study.
dc.identifier.doi10.1002/cbdv.202401857
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid39327818
dc.identifier.scopus2-s2.0-85208202473
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/cbdv.202401857
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24586
dc.identifier.wosWOS:001357314500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPhenolic Metal-Organic Frameworks
dc.subjectHematoxylin
dc.subjectAntimicrobial/antioxidant MOFs
dc.subjectBiocompatible MOFs
dc.subjectAlpha-glucosidase inhibitors
dc.titleBio-MOFs Based on Natural Phenolic, Hematoxylin Leverages Biomedical Applications: Enzyme Inhibition, Antioxidant, and Antibacterial Properties
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Nurettin Sahiner_Makale.pdf
Boyut:
6.84 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyomühendislik Bölümü Koleksiyonu
Kimya Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu