Biological Activities and Biochemical Composition of Endemic Achillea fraasii

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dc.authorid0000-0001-5556-4880en_US
dc.authorscopusid57205553123en_US
dc.authorwosidW-4530-2019en_US
dc.contributor.authorTunca-Pınarlı, Yağmur
dc.contributor.authorBenek, Atakan
dc.contributor.authorTuru, Dilay
dc.contributor.authorBozyel, Mustafa Eray
dc.contributor.authorCanlı, Kerem
dc.contributor.authorAltuner, Ergin Murat
dc.date.accessioned2024-01-24T06:55:27Z
dc.date.available2024-01-24T06:55:27Z
dc.date.issued2023en_US
dc.departmentFakülteler, Fen Fakültesi, Biyoloji Bölümü
dc.description.abstractIn this study, we investigated the antimicrobial, antioxidant, and antibiofilm activities and the biochemical composition of Achillea fraasii. The antimicrobial activity of A. fraasii ethanol extract (AFEt) was tested against 48 strains, and this is the first study testing the antimicrobial activity of this plant to this extent. The antioxidant activity was determined using the DPPH assay, and the antibiofilm activity of A. fraasii aqueous extract (AFAq) against five strains was assessed. The chemical composition of the plant extract was determined using GC-MS with artemisia ketone (19.41%) as the main component. The findings indicated that AFEt displayed antimicrobial activity against 38 strains, with a particular efficacy observed against various Staphylococcus aureus strains, such as S. aureus ATCC 25923, clinically isolated, multidrug resistant (MDR), and methicillin-resistant (MRSA) strains. In addition, the highest activity was observed against Enterococcus faecium. Moreover, the extract demonstrated activity against Candida strains. The plant extract also showed relatively good antioxidant activity compared to ascorbic acid, with an EC50 value of 55.52 µg/mL. However, AFAq acted as a biofilm activator against Escherichia coli ATCC 25922, increasing the biofilm formation by 2.63-fold. In conclusion, our study demonstrates the potential of A. fraasii as a source of antimicrobial and antioxidant agents.en_US
dc.identifier.citationTunca-Pınarlı, Y., Benek, A., Turu, D., Bozyel, M. E., Canlı, K., & Altuner, E. M. (2023). Biological Activities and Biochemical Composition of Endemic Achillea fraasii. Microorganisms, 11(4). https://doi.org/10.3390/microorganisms11040978en_US
dc.identifier.doi10.3390/microorganisms11040978
dc.identifier.issn2076-2607
dc.identifier.issue4en_US
dc.identifier.pmid37110401
dc.identifier.scopus2-s2.0-85156254702
dc.identifier.urihttps://doi.org/10.3390/microorganisms11040978
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5365
dc.identifier.volume11en_US
dc.identifier.wosWOS:000978141300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBozyel, Mustafa Eray
dc.language.isoen
dc.publisherMDPIen_US
dc.relation.ispartofMicroorganismsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAchillea fraasiien_US
dc.subjectAntibacterial activityen_US
dc.subjectAntibiofilm activityen_US
dc.subjectAntifungal activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectGC-MSen_US
dc.titleBiological Activities and Biochemical Composition of Endemic Achillea fraasii
dc.typeArticle

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