Impact of Valerian (Valeriana officinalis) Extract Supplementation on Common Carp (Cyprinus carpio L.) Growth Performance, Immune Responses, and Gene Expression

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dc.authoridYılmaz, Sevdan / 0000-0002-4809-5809
dc.contributor.authorYılmaz, Ebru
dc.contributor.authorMotlagh, Hamidreza Ahmadniaye
dc.contributor.authorYılmaz, Sevdan
dc.date.accessioned2025-05-29T02:57:39Z
dc.date.available2025-05-29T02:57:39Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study evaluated the effects of dietary supplementation with valerian (Valeriana officinalis) extract on growth performance, immune responses, and gene expression in common carp (Cyprinus carpio). Four experimental diets (V-0, V-0.25, V-0.5, and V-1) containing 0%, 0.25%, 0.5%, and 1% valerian extract were administered for 30 days. Dietary supplementation did not significantly influence growth performance (p > 0.05). Glutathione peroxidase (GPX) activity remained unchanged except in the high-dose group (V-1), while malondialdehyde (MDA) activity was significantly reduced in the V-0.25 group (p < 0.05). Aspartate aminotransferase (AST) activity increased in the V-1 group (p < 0.05), whereas alanine aminotransferase (ALT) activity decreased in the V-0.25 group (p < 0.05). Albumin (ALB) levels were elevated in the V-1 group (p < 0.05), while globulin (GLB) levels increased in all valerian-supplemented groups (p < 0.05). Creatinine (CRT) levels rose significantly only in the V-1 group (p < 0.05), and cholesterol levels decreased in the 0.5% and 1% groups (p < 0.05). Gene expression analysis revealed an increase in interleukin-1 beta (IL-1 beta) expression in the V-0.5 group (p < 0.05) but reductions in IL-10 and heat shock protein 70 (HSP70) in the V-0.25 group (p < 0.05). Superoxide dismutase (SOD) and catalase (CAT) gene expression levels significantly decreased in the groups fed with 0.25% and 0.5% valerian extract (p < 0.05), while catalase (CAT) gene expression levels significantly decreased in the groups fed with 0.25% and 0.5% valerian extract (p < 0.05). GPX gene expression levels declined across all experimental groups (p < 0.05). Tumor necrosis factor alpha (TNF-alpha) gene expression showed no significant changes (p > 0.05). These findings highlight the potential of valerian extract as a functional feed additive. However, further research with extended feeding durations and varying doses is required to understand its physiological effects in aquaculture better.
dc.description.sponsorshipAydin Adnan Menderes University, Collaborative Research Projects (ADU-BAP) [ZRF-23014]
dc.description.sponsorshipThis study wasfinancially supported by Aydin Adnan Menderes University, Collaborative Research Projects (ADU-BAP), with the project number ZRF-23014.
dc.identifier.doi10.1155/are/7950238
dc.identifier.issn1355-557X
dc.identifier.issn1365-2109
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105002130827
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/are/7950238
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30124
dc.identifier.volume2025
dc.identifier.wosWOS:001447606000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAquaculture Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectcommon carp
dc.subjectgene expression
dc.subjectimmune responses
dc.subjectValeriana officinalis
dc.titleImpact of Valerian (Valeriana officinalis) Extract Supplementation on Common Carp (Cyprinus carpio L.) Growth Performance, Immune Responses, and Gene Expression
dc.typeArticle

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