Enhancement of biocompatibility and carbohydrate absorption control potential of rosmarinic acid through crossinking into microparticles

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dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorBlake, Diane A.
dc.contributor.authorFullerton, Mitchell L.
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorSunol, Aydın K.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:14:13Z
dc.date.available2025-01-27T20:14:13Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractRosmarinic acid (RA), a bioflavonoid and antioxidant that exists in plants of the Lamiaceae family, was crosslinked into particles as poly(Rosmarinic Acid) (p(RA)) via an emulsion crosslinking method. The particles were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, solid state nuclear magnetic resonance C-13 NMR spectroscopy, and thermal gravimetric analysis. The zeta potential values of p(RA) particles were determined at different pHs; the isoelectric point was estimated as pH 1.2. The release of monomeric RA from the particles at 37.5 degrees C was found to be similar at different pHs, 1.0, 7.4, and 11.0. The effects of p(RA) on hemolysis and coagulation were found to be minimal. The antioxidant activity of p(RA) particles and RA monomer were almost indistinguishable suggesting that p(RA) particles may be used as an antioxidant. On a per weight basis, p(RA) particles were similar to 66% less cytotoxic to mammalian cells that RA monomer, as assessed using COS-1 cells. In addition, p(RA) was an 8.6-fold stronger inhibitor of alpha-glycosidase than RA; the IC(50)s of the monomer and particles were 0.121 and 0.014 mg/mL, respectively. The strong inhibitory effect of p(RA) on alpha-glycosidase, coupled with its reduced cytotoxicity and antioxidant activity, provide new opportunities for the use of p(RA). (C) 2019 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [BIDEB-2219, 10598191600622]
dc.description.sponsorshipThis research was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) BIDEB-2219 Postdoctoral Research program grant number 10598191600622.
dc.identifier.doi10.1016/j.ijbiomac.2019.07.032
dc.identifier.endpage843
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid31284004
dc.identifier.scopus2-s2.0-85068549186
dc.identifier.scopusqualityQ1
dc.identifier.startpage836
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.07.032
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21002
dc.identifier.volume137
dc.identifier.wosWOS:000484644100091
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectRosmarinic acid particles
dc.subjectAntioxidant microgel/nanogel
dc.subjectInhibition of alpha-glucosidase activity
dc.titleEnhancement of biocompatibility and carbohydrate absorption control potential of rosmarinic acid through crossinking into microparticles
dc.typeArticle

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