Correlation between vaspin and PANSS scores in schizophrenia patients with obesity

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dc.contributor.authorErtekin, Hulya
dc.contributor.authorUysal, Sema
dc.contributor.authorAydin, Memduha
dc.contributor.authorIlhan, Bilge
dc.contributor.authorErtekin, Yusuf Haydar
dc.date.accessioned2025-01-27T20:57:50Z
dc.date.available2025-01-27T20:57:50Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Metabolic abnormalities such as diabetes, dyslipidemia, abdominal obesity, metabolic syndrome, and abnormal levels of plasma adipokines have been observed in patients with schizophrenia. This study aimed to investigate the differences and correlations of plasma vaspin levels with metabolic parameters in patients with schizophrenia and to compare with healthy controls. Method: We measured plasma levels of vaspin and metabolic parameters of 100 patients with schizophrenia and 95 healthy controls. Patients with schizophrenia were evaluated with the Positive and Negative Syndrome Scale (PANSS) and The Global Assessment of Functioning. Results: Mean levels of body mass index, waist circumference, triglyceride, and low-density lipoprotein cholesterol of the patients were statistically higher than those of the healthy controls (p = 0.002, p < 0.001, p = 0.03, and p = 0.002, respectively). Plasma levels of vaspin were 0.96 +/- 0.73 ng/ml in patients with schizophrenia and 0.29 +/- 0.15 ng/ml in the healthy controls (p < 0.001). Plasma vaspin levels were statistically higher in patients with schizophrenia than healthy controls both in groups with and without metabolic syndrome and obesity (p < 0.001). Plasma vaspin levels showed a positive correlation with triglyceride in patients with schizophrenia (r = 0.26, p = 0.007). There were positive correlations between vaspin and PANSS scores in schizophrenia patients with obesity (PANSS Positive: r = 0.42, p = 0.01; PANSS Negative: r = 0.42, p = 0.01; PANSS General: r = 0.43, p = 0.01; PANSS Total: r = 0.47, p = 0.006). Conclusions: Our study showed a significant relationship and positive correlation between vaspin and PANSS scores in schizophrenia patients with obesity. Vaspin may play an important role in the metabolic processes of patients with schizophrenia.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit [TSA-2015-561]
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was carried out with the support of Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit with the project number TSA-2015-561.
dc.identifier.doi10.1177/0091217420905463
dc.identifier.endpage280
dc.identifier.issn0091-2174
dc.identifier.issn1541-3527
dc.identifier.issue4
dc.identifier.pmid32050814
dc.identifier.scopus2-s2.0-85079413258
dc.identifier.scopusqualityQ3
dc.identifier.startpage264
dc.identifier.urihttps://doi.org/10.1177/0091217420905463
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26521
dc.identifier.volume55
dc.identifier.wosWOS:000513412900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofInternational Journal of Psychiatry in Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectadipokines
dc.subjectschizophrenia
dc.subjectobesity
dc.subjectmetabolic syndrome
dc.subjectvaspin
dc.subjectinsulin resistance
dc.titleCorrelation between vaspin and PANSS scores in schizophrenia patients with obesity
dc.typeArticle

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