Changes Induced by Copper Toxicity in the Rat Liver and the Effects of Panax Ginseng on These Changes

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dc.authoridBoyacioglu, Murat/0000-0001-6952-8637
dc.contributor.authorYildiz, M.
dc.contributor.authorBoyacioglu, M.
dc.contributor.authorAvcioglu, M.
dc.contributor.authorElmas, Sait
dc.date.accessioned2025-01-27T20:41:14Z
dc.date.available2025-01-27T20:41:14Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCopper is a trace element that accumulates in the body and forms harmful effects. Panax ginseng is a plant that possesses antioxidant properties. The purpose of this study is to evaluate whether Panax ginseng protects the livers of rats exposed to copper sulfate. The rats were randomly divided into four groups as control, Panax ginseng, copper sulfate and Panax ginseng + copper sulfate. At the end of the trial, blood and liver samples were obtained from the animals. Biochemical analysis was carried out in blood samples. Oxidant and antioxidant parameters were analyzed in liver samples. In addition, liver tissue sections were stained with the hematoxylin-eosin, Masson's trichrome, periodic acid-Schiff, and rhodanine staining methods for histochemical and histopathological examinations. It was found that serum alanine transaminase (ALT) and aspartate transaminase (AST) levels, also densities of copper and histopathological parameters except for central vein dilatation and malondialdehyde (MDA) value in the liver significantly increased in copper sulfate group compared to control group, but inflammatory cell infiltration and MDA value decreased in Panax ginseng + copper sulfate group compared to copper sulfate group. In addition, it was determined that glycogen density, glutathione (GSH) level and superoxide dismutase (SOD) activity in the liver significantly decreased in copper sulfate group compared to control group, and they increased in Panax ginseng + copper sulfate group compared to copper sulfate group. As a result, copper sulfate causes structural and oxidative abnormalities in the liver. Additionally, Panax ginseng helps to protect liver tissue by diminishing oxidative damage in copper sulfate toxicity.
dc.description.sponsorshipCanakkale Onsekiz Mart University Experimental Researches Application and Research Center, Turkey
dc.description.sponsorshipThe research was performed at Canakkale Onsekiz Mart University Experimental Researches Application and Research Center, Turkey. Also, we are grateful to Associate Prof. Yonca Betil Kabak for his support.
dc.identifier.doi10.1134/S1062359023604731
dc.identifier.endpageS707
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issueSUPPL 4
dc.identifier.scopus2-s2.0-85186421300
dc.identifier.scopusqualityQ4
dc.identifier.startpageS694
dc.identifier.urihttps://doi.org/10.1134/S1062359023604731
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24075
dc.identifier.volume50
dc.identifier.wosWOS:001172984100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofBiology Bulletin
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectantioxidant
dc.subjectcopper sulfate
dc.subjectPanax ginseng
dc.subjectliver
dc.subjectrat
dc.titleChanges Induced by Copper Toxicity in the Rat Liver and the Effects of Panax Ginseng on These Changes
dc.typeArticle

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