Cone beam computed tomography vs. microcomputed tomography for trabecular bone healing assessment

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dc.authoridDeniz, Yeşim / 0000-0002-6967-5378
dc.authoridÇetin Genç, Çiğdem / 0000-0001-6745-3790
dc.contributor.authorDeniz, Yeşim
dc.contributor.authorÇetin Genç, Çiğdem
dc.contributor.authorOrhan, Kaan
dc.date.accessioned2026-02-03T12:03:08Z
dc.date.available2026-02-03T12:03:08Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose This study aimed to compare cone beam computed tomography (CBCT) and microcomputed tomography (μCT) data to evaluate the micromorphological structure of healing bone in defects created on rabbit mandibles at different stages. Methods Residual rabbit mandibular alveolar bone tissues from another animal study involving 18 rabbits were utilized. In the prior study, 10 × 4 mm bone cavities were created, left to heal naturally, and the animals were sacrificed after 21, 45, and 90 days. In this study, CBCT and μCT imaging were performed on the excised defect regions. The micromorphometry parameters including bone–volume fraction (BV/TV), bone–surface density (BS/TV), fractal dimension, connectivity density (Conn. Dn.), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp) were examined by ImageJ (US National Institutes of Health, Bethesda, MD, USA). Paired two-sample t‑tests, Wilcoxon test, and Bland–Altman plots were performed. Result Differences in the parameters Conn. Dn., fractal dimension, Tb.Th, and Tb.Sp were observed between CBCT and μCT on day 21. By day 45, no significant differences were noted in BV/TV, BS/TS, Tb.Th, and Tb.Sp. On day 90, all measured parameters showed no statistically significant differences between CBCT and μCT. Bland–Altman analysis showed an agreement for most parameters (BV/TV, BS/TV, fractal dimension, Tb.Th, and Tb.Sp) after 21, 45, and 90 days, with minimal biases emerging over time, while a more notable divergence in Conn. Dn. was observed. Conclusion CBCT can be used for micromorphological analyses on days 45 and 90 of bone healing as there were no differences between CBCT and μCT during these periods.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Foundation [TSA-2023-4133]
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Foundation has supported this study (Proc. TSA-2023-4133).
dc.identifier.doi10.1007/s00056-025-00589-8
dc.identifier.issn1434-5293
dc.identifier.issn1615-6714
dc.identifier.pmid40392312
dc.identifier.scopus2-s2.0-105005544153
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00056-025-00589-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34984
dc.identifier.wosWOS:001491332300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Orofacial Orthopedics-Fortschritte Der Kieferorthopadie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectOsteogenesis
dc.subjectBone formation
dc.subjectThree-dimensional imaging
dc.subjectComputer-assisted radiographic image interpretation
dc.subjectX-ray microtomography
dc.titleCone beam computed tomography vs. microcomputed tomography for trabecular bone healing assessment
dc.typeArticle

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