Clinical Applications of Bovine Colostrum in GastrointestinaI Disorders: Mechanisms, Evidence, and Therapeutic Potential

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dc.authoridKarakülah, Yusuf Serhat / 0009-0006-2304-3494
dc.authoridYalçıntaş, Yalçın Mert / 0009-0008-0447-1076
dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorKarakülah, Yusuf Serhat
dc.contributor.authorYalçıntaş, Yalçın Mert
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T11:59:59Z
dc.date.available2026-02-03T11:59:59Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBovine colostrum stands out as a natural supplement with rich bioactive components that attract attention for its therapeutic potential in the maintenance and improvement of gastrointestinal (GI) health. The major bioactive components of bovine colostrum include immunoglobulin (Ig) (especially immunoglobulin G), lactoferrin (LF), growth Factors (IGF-I, TGF-beta, EGF), oligosaccharides (OS), and bioactive peptides. These components play a role in epithelial repair, suppression of inflammation, balancing the microbiota, and enhancing the mucosal barrier. Various animal models and recent human studies show that bovine colostrum has various positive effects against gastrointestinal tract diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), non-steroidal anti-Inflammatory drug (NSAID)-induced enteropathy, and necrotizing enterocolitis (NEC). These effects include preservation of epithelial integrity, reduction of inflammatory markers, and improvement of intestinal permeability. Studies on the tolerability and efficacy profiles of various bovine colostrum formulations for oral, oropharyngeal, and enteral administration are increasing. In this review, the multifaceted effects of bovine colostrum on the gastrointestinal tract are explained at a mechanistic level, and potential areas of study for clinical translation are presented. Bovine Colostrum stands out as a promising natural biotherapeutic agent for both preventive and therapeutic approaches.
dc.identifier.doi10.3390/ijms262110673
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue21
dc.identifier.pmid41226709
dc.identifier.scopus2-s2.0-105021616578
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms262110673
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34454
dc.identifier.volume26
dc.identifier.wosWOS:001612738300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectcolostrum
dc.subjectgastrointestinal
dc.subjectlactoferrin
dc.subjecttherapeutic
dc.subjectclinical
dc.titleClinical Applications of Bovine Colostrum in GastrointestinaI Disorders: Mechanisms, Evidence, and Therapeutic Potential
dc.typeReview Article

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