Poly(vinyl amine) microparticles derived from N-Vinylformamide and their versatile use

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dc.authorscopusid56026625600en_US
dc.authorscopusid57218921322en_US
dc.authorscopusid6602001525en_US
dc.authorwosidHQZ-4087-2023en_US
dc.authorwosidJLK-9360-2023en_US
dc.authorwosidKVP-4764-2024en_US
dc.contributor.authorDemirci, Şahin
dc.contributor.authorSutekin, S. Duygu
dc.contributor.authorKurt, Saliha B.
dc.contributor.authorGüven, Olgun
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-02-06T10:19:32Z
dc.date.available2025-02-06T10:19:32Z
dc.date.issued2022en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümüen_US
dc.departmentRektörlük, Rektörlüğe Bağlı Bölümler, Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezien_US
dc.description.abstractCationic polymers with primary amine groups that can easily be functionalized or coupled with substrates by complexation or hydrogen bonding are especially advantageous in preparing particles for biomedical applications. Poly(vinyl amine) (PVAm) is a cationic polyelectrolyte containing the highest number of primary amine groups among any other polymers. Here, we introduce a general method in synthesizing PVAm microparticles via a surfactant-free water-in-oil emulsion technique using cyclohexane as the oil phase and aqueous PVAm solution as the dispersed phase. PVAm particles were prepared to employ two different bifunctional chemical crosslinkers, divinyl sulfone (DVS) and poly(ethylene glycol) diglycidyl ether (PEGGE). The prepared particles were further treated with HCl to protonate the amine groups of PVAm within particles. The effect of crosslinker types and pH on the hydrolytic degradation of PVAm particles were also investigated at three different solution pHs, 5.4, 7.4, and 9, to simulate the skin, blood, and intestinal pH environments, respectively. The blood compatibility of the PVAm particles was evaluated by in vitro hemolysis and blood clotting assays. Furthermore, antifungal and antibacterial efficacy of PVAm-based particles and their protonated forms were tested against C. albicans yeast and E. coli, S. aureus, B. subtilis, and P. aeruginosa bacterial strains.en_US
dc.identifier.citationDemirci, Ş., Sütekin, S. D., Kurt, S. B., Güven, O., & Şahiner, N. (2022). Poly(vinyl amine) microparticles derived from N-Vinylformamide and their versatile use. Polymer Bulletin, 79(9), 7729–7751. https://doi.org/10.1007/s00289-021-03874-9en_US
dc.identifier.doi10.1007/s00289-021-03874-9en_US
dc.identifier.endpage7751en_US
dc.identifier.issn0170-0839 / 1436-2449
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85114172275en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage7729en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-021-03874-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29566
dc.identifier.volume79en_US
dc.identifier.wosWOS:000692621900001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDemirci, Şahin
dc.institutionauthorKurt, Saliha B.
dc.institutionauthorŞahiner, Nurettin
dc.institutionauthorid0000-0001-7083-1481
dc.institutionauthorid0000-0003-0346-441X
dc.institutionauthorid0000-0003-0120-530X
dc.language.isoengen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofPolymer Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial/antifungal materialen_US
dc.subjectBlood compatibleen_US
dc.subjectPoly(vinyl amine)en_US
dc.subjectPolymeric microparticlesen_US
dc.titlePoly(vinyl amine) microparticles derived from N-Vinylformamide and their versatile useen_US
dc.typearticleen_US

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