Poly(vinyl amine) microparticles derived from N-Vinylformamide and their versatile use
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Science and Business Media Deutschland GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cationic polymers with primary amine groups that can easily be functionalized or coupled with substrates by complexation or hydrogen bonding are especially advantageous in preparing particles for biomedical applications. Poly(vinyl amine) (PVAm) is a cationic polyelectrolyte containing the highest number of primary amine groups among any other polymers. Here, we introduce a general method in synthesizing PVAm microparticles via a surfactant-free water-in-oil emulsion technique using cyclohexane as the oil phase and aqueous PVAm solution as the dispersed phase. PVAm particles were prepared to employ two different bifunctional chemical crosslinkers, divinyl sulfone (DVS) and poly(ethylene glycol) diglycidyl ether (PEGGE). The prepared particles were further treated with HCl to protonate the amine groups of PVAm within particles. The effect of crosslinker types and pH on the hydrolytic degradation of PVAm particles were also investigated at three different solution pHs, 5.4, 7.4, and 9, to simulate the skin, blood, and intestinal pH environments, respectively. The blood compatibility of the PVAm particles was evaluated by in vitro hemolysis and blood clotting assays. Furthermore, antifungal and antibacterial efficacy of PVAm-based particles and their protonated forms were tested against C. albicans yeast and E. coli, S. aureus, B. subtilis, and P. aeruginosa bacterial strains.
Açıklama
Anahtar Kelimeler
Antibacterial/antifungal material, Blood compatible, Poly(vinyl amine), Polymeric microparticles
Kaynak
Polymer Bulletin
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
79
Sayı
9
Künye
Demirci, Ş., Sütekin, S. D., Kurt, S. B., Güven, O., & Şahiner, N. (2022). Poly(vinyl amine) microparticles derived from N-Vinylformamide and their versatile use. Polymer Bulletin, 79(9), 7729–7751. https://doi.org/10.1007/s00289-021-03874-9
