Humic acid attenuates cisplatin-induced nephrotoxicity in rats

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dc.contributor.authorTekes, Ender
dc.contributor.authorGulen, Meltem Ickin
dc.contributor.authorSilan, Coskun
dc.contributor.authorBagla, Aysel Guven
dc.date.accessioned2025-05-29T02:57:47Z
dc.date.available2025-05-29T02:57:47Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCisplatin-induced nephrotoxicity, a major limitation of this chemotherapeutic agent, involves oxidative stress, inflammation, and apoptosis. This study investigated the potential renoprotective effects of humic acid in a rat model of cisplatin-induced nephrotoxicity. Forty-two male Wistar rats were assigned to six groups: control, humic acid, cisplatin, cisplatin + humic acid 10 mg/kg, cisplatin + humic acid 20 mg/kg, and cisplatin + humic acid 40 mg/kg. On day 7, the rats were sacrificed, and cardiac blood and kidneys were collected for biochemical and histopathological examinations. Humic acid administration significantly attenuated the cisplatin-induced increases in renal TNF-alpha and NF-kappa B levels, indicating a reduction in inflammation. Humic acid also ameliorated histopathological damage, including Bowman's capsule dilatation, tubular cell degeneration, and hemorrhage. However, humic acid did not significantly alter oxidative stress parameters or caspase-3 levels. Humic acid demonstrates a protective effect against cisplatin-induced nephrotoxicity in rats, primarily by mitigating the inflammatory response. While HA's beneficial effects on oxidative stress and apoptosis were limited in this study, its ability to reduce inflammation highlights its potential as a therapeutic strategy to mitigate cisplatin-induced kidney injury.
dc.description.sponsorshipCanakkale Onsekiz Mart University, The Scientific Research Projects Coordination Unit [TSA-2020- 3394]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University, The Scientific Research Projects Coordination Unit under Grant TSA-2020- 3394. Graphical abstract was created using BioRender.com (Tekes, E., 2024. Available at https://BioRender.com/g22u453).
dc.identifier.doi10.1080/01480545.2025.2453590
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid39871462
dc.identifier.scopus2-s2.0-85216564608
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/01480545.2025.2453590
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30175
dc.identifier.wosWOS:001407669900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectAnti-inflammatory
dc.subjectantioxidant
dc.subjectcisplatin
dc.subjecthumic acid
dc.subjectnephrotoxicity
dc.titleHumic acid attenuates cisplatin-induced nephrotoxicity in rats
dc.typeArticle

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