Decoy oligodeoxynucleotides targeting STATs in non-cancer gene therapy

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dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorMahjoubin-Tehran, Maryam
dc.contributor.authorRezaei, Samaneh
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorKarav, Sercan
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2025-05-29T02:58:00Z
dc.date.available2025-05-29T02:58:00Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe Signal Transducer and Activator of Transcription (STAT) protein family is crucial for organizing the epigenetic configuration of immune cells and controlling various fundamental cell physiological functions including apoptosis, development, inflammation, immunological responses, and cell proliferation and differentiation. The human genome has seven known STAT genes, named 1, 2, 3, 4, 5a, 5b, and 6. Aberrant activation of STAT signaling pathways is associated with many human disorders, particularly cardiovascular diseases (CVDs), making these proteins promising therapeutic targets. Improved understanding of altered and pathological gene expression and its role in the pathophysiology of various hereditary and acquired disorders has enabled the development of novel treatment approaches based on gene expression modulation. One such promising development is the oligodeoxynucleotide decoy method, which may allow researchers to specifically influence gene activation or repression. Various oligodeoxynucleotide decoys target STATs and affect the expression of its downstream genes. We summarized cell culture and preclinical research, which evaluated the effects of oligodeoxynucleotide decoys target STATs in different types of non-cancer illnesses.
dc.identifier.doi10.1016/j.gene.2025.149482
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.pmid40216342
dc.identifier.scopus2-s2.0-105002217490
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.gene.2025.149482
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30234
dc.identifier.volume957
dc.identifier.wosWOS:001469931600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofGene
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectDecoy oligodeoxynucleotides
dc.subjectSTAT
dc.subjectSTAT3
dc.subjectSignal transducer
dc.subjectCell processes
dc.titleDecoy oligodeoxynucleotides targeting STATs in non-cancer gene therapy
dc.typeReview

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