Curcumin-based nanofibers: A promising approach for cancer therapy

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dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorRahiman, Niloufar
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorKarav, Sercan
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2025-05-29T02:57:57Z
dc.date.available2025-05-29T02:57:57Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNanofibers are among the promising platforms for efficient delivery of drugs (both hydrophilic and hydrophobic) through harnessing polymers with different natures as their base. Hydrophobic low-solubility agents such as curcumin could be incorporated in various types of electrospun nanofibers for different aims in drug delivery, such as enhancing its solubility, making this agent sustained release with improved pharmacological efficacy. Through using this nanoplatform, curcumin may become more bioavailable and more efficcious in the field of cancer therapy as well as tissue engineering and wound healing for local delivery of this anti-inflammatory and antioxidant agent. In this review, the characteristics of curcumin-loaded nanofibers, their targeting potential or stimuli-responsiveness accompanied with therapeutic anti-cancerous applications of them (mostly in local application) are securitized. These nanofibers follow the aim of enhancing curcumin's therapeutic effectiveness and release profile. We laso elaborate on the mechanisms of action through which curcumin exerts its effect on various cancerous cells after its incorporation in various types of nanofibers which have been prepared by exploiting different polymers.
dc.identifier.doi10.1016/j.prp.2024.155791
dc.identifier.issn0344-0338
dc.identifier.issn1618-0631
dc.identifier.pmid39742832
dc.identifier.scopus2-s2.0-85219499249
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.prp.2024.155791
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30208
dc.identifier.volume266
dc.identifier.wosWOS:001420293800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofPathology Research and Practice
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectNanofibers
dc.subjectDrug delivery
dc.subjectSolubility
dc.subjectCurcumin
dc.subjectTissue engineering
dc.subjectWound healing
dc.subjectPolymers
dc.titleCurcumin-based nanofibers: A promising approach for cancer therapy
dc.typeReview

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