Potential Applications of Endo-beta-N-Acetylglucosaminidases From Bifidobacterium longum Subspecies infantis in Designing Value-Added, Next-Generation Infant Formulas

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dc.authorid-en_US
dc.authorid-en_US
dc.authorid-en_US
dc.authorid0000-0003-1183-3553en_US
dc.authorid0000-0003-4056-1673en_US
dc.authorscopusid57221201493en_US
dc.authorscopusid57210425578en_US
dc.authorscopusid57210429018en_US
dc.authorscopusid56503962600en_US
dc.authorscopusid56688659000en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosidGZK-9987-2022en_US
dc.authorwosidT-8649-2018en_US
dc.contributor.authorDuman, Hatice
dc.contributor.authorKaplan, Merve
dc.contributor.authorArslan, Ayşenur
dc.contributor.authorŞahutoglu, Arif Sercan
dc.contributor.authorKarav, Sercan
dc.contributor.authorKayılı, Hacı Mehmet
dc.contributor.authorFrese, Steven A.
dc.date.accessioned2023-07-11T06:28:33Z
dc.date.available2023-07-11T06:28:33Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractHuman milk is the optimal source of infant nutrition. Among many other health benefits, human milk can stimulate the development of a Bifidobacterium-rich microbiome through human milk oligosaccharides (HMOs). In recent years, the development of novel formulas has placed particular focus on incorporating some of the beneficial functional properties of human milk. These include adding specific glycans aimed to selectively stimulate the growth of Bifidobacterium. However, the bifidogenicity of human milk remains unparalleled. Dietary N-glycans are carbohydrate structures conjugated to a wide variety of glycoproteins. These glycans have a remarkable structural similarity to HMOs and, when released, show a strong bifidogenic effect. This review discusses the biocatalytic potential of the endo-β-N-acetylglucosaminidase enzyme (EndoBI-1) from Bifidobacterium longum subspecies infantis (B. infantis), in releasing N-glycans inherently present in infant formula as means to increase the bifidogenicity of infant formula. Finally, the potential implications for protein deglycosylation with EndoBI-1 in the development of value added, next-generation formulas are discussed from a technical perspective.en_US
dc.identifier.citationDuman, H., Kaplan, M., Arslan, A., Şahutoğlu, A. S., Kayılı, H. M., Frese, S. A., & Karav, S. (2021). Potential applications of endo-β-N-acetylglucosaminidases from bifidobacterium longum subspecies infantis in designing value-added, next-generation infant formulas. Frontiers in Nutrition, 8 doi:10.3389/fnut.2021.646275en_US
dc.identifier.doi10.3389/fnut.2021.646275
dc.identifier.issn2296-861X
dc.identifier.pmid33898500
dc.identifier.scopus2-s2.0-85105104117
dc.identifier.urihttps://doi.org/10.3389/fnut.2021.646275
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4353
dc.identifier.volume8en_US
dc.identifier.wosWOS:000642518900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDuman, Hatice
dc.institutionauthorKaplan, Merve
dc.institutionauthorArslan, Ayşenur
dc.institutionauthorŞahutoğlu, Arif Sercan
dc.institutionauthorKarav, Sercan
dc.language.isoen
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Nutritionen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBifidobacteriaen_US
dc.subjectEndo-β-N-acetylglucosaminidaseen_US
dc.subjectHuman milk oligosaccharidesen_US
dc.subjectInfant formulaen_US
dc.subjectN-glycansen_US
dc.titlePotential Applications of Endo-beta-N-Acetylglucosaminidases From Bifidobacterium longum Subspecies infantis in Designing Value-Added, Next-Generation Infant Formulas
dc.typeReview Article

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