Could elevated platelet-lymphocyte ratio predict left ventricular systolic dysfunction in patients with non-ST elevated acute coronary syndrome?

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dc.contributor.authorBekler, Adem
dc.contributor.authorGazi, Emine
dc.contributor.authorYilmaz, Mustafa
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorAltun, Burak
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorPeker, Tezcan
dc.date.accessioned2025-01-27T20:11:53Z
dc.date.available2025-01-27T20:11:53Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The prognostic value of a high platelet-lymphocyte ratio (PLR) has been reported in patients with non-ST elevated myocardial infarction (NSTEMI) and different oncologic disorders. We aimed to evaluate the predictive value of the PLR for left ventricular systolic dysfunction (LVSD) in patients with non-ST elevated acute coronary syndrome (NST-ACS). Methods: A total of 220 patients with NST-ACS were included in the study. The study population was divided into tertiles based on admission PLR values. High (n=73) and low PLR (n=147) groups were defined as patients having values in the third tertile (>135.6) and lower 2 tertiles (<= 135.6), respectively. Left ventricular dysfunction was defined as ejection fraction <= 40%, and related variables were evaluated by backward conditional binary logistic regression analysis. Results: The patients in the high PLR group were older (p<0.001) and had a higher rate of previous myocardial infarction and NSTEMI (p=0.046, p=0.013, respectively). There were significantly more coronary arteries narrowed (p=0.001) and lower left ventricular ejection fraction (p<0.001) in the high PLR group. Baseline platelet levels were significantly higher (p<0.001) and triglyceride and lymphocyte levels were significantly lower (p=0.009 and p<0.001, respectively) in the high PLR group. PLR >135.6 was found to be an independent predictor of systolic dysfunction in the multivariate analyses (beta: 0.306, 95% confidence interval: 0.151-0.619; p=0.001). Conclusion: A high PLR is a strong and independent predictor for LVSD in patients with NST-ACS.
dc.identifier.doi10.5152/akd.2014.5434
dc.identifier.endpage390
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue5
dc.identifier.pmid25430405
dc.identifier.scopus2-s2.0-84979098663
dc.identifier.scopusqualityN/A
dc.identifier.startpage385
dc.identifier.trdizinid262096
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5434
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/262096
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20765
dc.identifier.volume15
dc.identifier.wosWOS:000355107300010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectacute coronary syndrome
dc.subjectmyocardial infarction
dc.subjectplatelet-lymphocyte ratio
dc.subjectventricular ejection fraction
dc.titleCould elevated platelet-lymphocyte ratio predict left ventricular systolic dysfunction in patients with non-ST elevated acute coronary syndrome?
dc.typeArticle

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