Microwave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a] pyrimidine containing tri/tetrasubstituted imidazole derivatives
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TUBITAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution 3.0 United States
Attribution 3.0 United States
Özet
A series of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized
via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2-a]pyrimidine-2-carbaldehyde, benzil, primary amines,
and ammonium acetate catalyzed by p-toluenesulfonic acid under microwave-assisted conditions. The results showed that target
compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields
(46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo[1,2-a]pyrimidine containing tri/
tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and
one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic
tools such as FT-IR, 1
H NMR, 13C NMR, and MS.
Açıklama
Anahtar Kelimeler
Imidazo[1,2-a]pyrimidine, Tri/tetrasubstituted imidazole, Microwave synthesis, Sequential, One-pot reaction, P-toluenesulfonic acid
Kaynak
Turkish Journal of Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
45
Sayı
1
Künye
Güngör, T. (2021). Microwave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a] pyrimidine containing tri/tetrasubstituted imidazole derivatives. Turkish Journal of Chemistry, 45(1), 219-230. doi:10.3906/kim-2009-40
