Physically Crosslinked Chondroitin Sulfate (CS)-Metal Ion (M: Fe(III), Gd(III), Zn(II), and Cu(II)) Particles for Versatile Applications and Their Biosafety

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dc.authorid0000-0002-3524-0675en_US
dc.authorid0000-0001-8666-7954en_US
dc.authorid0000-0003-0120-530Xen_US
dc.authorscopusid57210429765en_US
dc.authorscopusid24472372400en_US
dc.authorscopusid6602001525en_US
dc.authorwosidU-5886-2019en_US
dc.authorwosidAAB-6714-2020en_US
dc.authorwosidDVD-0927-2022en_US
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorUmut, Evrim
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2024-01-24T06:31:33Z
dc.date.available2024-01-24T06:31:33Z
dc.date.issued2023en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.departmentRektörlük, Rektörlüğe Bağlı Bölümler, Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezi
dc.description.abstractChondroitin sulfate (CS), a well-known glycosaminoglycan, was physically crosslinked with Fe(III), Gd(III), Zn(II), and Cu(II) ions to obtain CS-Fe(III), CS-Gd(III), CS-Zn(II), and CS-Cu(II) polymeric particles for multipurpose biological applications. The CS–metal ion-containing particles in the micrometer to a few hundred nanometer size range are injectable materials for intravenous administration. The CS–metal ion-containing particles are safe biomaterials for biological applications because of their perfect blood compatibility and no significant cytotoxicity on L929 fibroblast cells up to a 10 mg/mL concentration. Furthermore, CS-Zn(II) and CS-Cu(II) particles show excellent antibacterial susceptibility, with 2.5–5.0 mg/mL minimum inhibition concentration (MIC) values against Escherichia coli and Staphylococcus aureus. Moreover, the in vitro contrast enhancement abilities of aqueous CS–metal ion particle suspensions in magnetic resonance imaging (MRI) were determined by obtaining T1- and T2-weighted MR images using a 0.5 Tesla MRI scanner and by calculating the water proton relaxivities. Therefore, these CS-Fe(III), CS-Gd(III), CS-Zn(II), and CS-Cu(II) particles have significant potential as antibacterial additive materials and MRI contrast enhancement agents with less toxicity.en_US
dc.identifier.citationSuner, S. S., Şahiner, M., Umut, E., Ayyala, R. S., & Şahiner, N. (2023). Physically Crosslinked Chondroitin Sulfate (CS)–Metal Ion (M: Fe(III), Gd(III), Zn(II), and Cu(II)) Particles for Versatile Applications and Their Biosafety. Pharmaceuticals, 16(4). https://doi.org/10.3390/ph16040483en_US
dc.identifier.doi10.3390/ph16040483
dc.identifier.issn1424-8247
dc.identifier.issue4en_US
dc.identifier.pmid37111240
dc.identifier.scopus2-s2.0-85154539596
dc.identifier.urihttps://doi.org/10.3390/ph16040483
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5360
dc.identifier.volume16en_US
dc.identifier.wosWOS:000977190800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSağbaş Suner, Selin
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofPharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAntibacterialen_US
dc.subjectBiocompatibleen_US
dc.subjectChondroitin sulfate (CS)en_US
dc.subjectCS–metal ion particlesen_US
dc.subjectMagnetic resonance imaging (MRI)en_US
dc.titlePhysically Crosslinked Chondroitin Sulfate (CS)-Metal Ion (M: Fe(III), Gd(III), Zn(II), and Cu(II)) Particles for Versatile Applications and Their Biosafety
dc.typeArticle

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