Biomechanical comparison of tigecycline loaded bone cement with vancomycin and daptomycin loaded bone cements

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dc.authoridKaratosun, Vasfi/0000-0002-0385-4840
dc.authoridUZUN, BORA/0000-0001-6638-1799
dc.contributor.authorMuratli, Sedit Kivanc
dc.contributor.authorKaratosun, Vasfi
dc.contributor.authorUzun, Bora
dc.contributor.authorGunal, Izge
dc.date.accessioned2025-01-27T20:39:28Z
dc.date.available2025-01-27T20:39:28Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The objectives of this study were 1 to analyze the compressive and tensile mechanical strength characteristics of tigecycline loaded bone cement and 2 to compare them with those of vancomycin and daptomycin loaded bone cements which are used in prosthetic joint infections complicated with resistant microorganisms. Methods: In this study, three experimental groups, which consisted of vancomycin (subgroups containing 1 g, 2 g, and 3 g vancomycin), daptomycin (subgroups containing 0.5 g, 1 g, and 1.5 g daptomycin), and tigecycline (subgroups containing 50 mg, 100 mg, and 150 mg tigecycline) and one control group without antibiotics were used. Using a standardized protocol, all antibiotic loaded bone cements were prepared. For each antibiotic group, including the control group, 10 samples were tested. All samples were biomechanically tested in terms of compressive strength and tensile strength. Results: Compression tests showed that all determined antibiotic concentrations resulted in a significant decrease when compared with the control group (p<0.0011). Vancomycin and daptomycin study groups demonstrated lower tensile strength than the control group (p<0.0011). However, comparison of tensile values of tigecycline study groups with the control group revealed no significant difference (p>0.0011). In addition, all statistically significant results from between groups comparisons revealed higher tensile and compressive mechanical strength values for the tigecycline groups (p<0.0011). Conclusion: Evidence from this study has demonstrated that tigecycline loaded bone cement may have no mechanical disadvantage compared with vancomycin and daptomycin loaded bone cements in terms of mechanical strength when used at defined concentrations.
dc.identifier.doi10.5152/j.aott.2020.19086
dc.identifier.endpage540
dc.identifier.issn1017-995X
dc.identifier.issue5
dc.identifier.pmid33155566
dc.identifier.scopus2-s2.0-85094559775
dc.identifier.scopusqualityQ2
dc.identifier.startpage535
dc.identifier.trdizinid416209
dc.identifier.urihttps://doi.org/10.5152/j.aott.2020.19086
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/416209
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23955
dc.identifier.volume54
dc.identifier.wosWOS:000583284400013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Orthopaedics Traumatology
dc.relation.ispartofActa Orthopaedica Et Traumatologica Turcica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectTigecycline
dc.subjectAntibiotic loaded bone cement
dc.subjectMechanical testing
dc.subjectProsthetic joint infection
dc.subjectLocal treatment of infection
dc.titleBiomechanical comparison of tigecycline loaded bone cement with vancomycin and daptomycin loaded bone cements
dc.typeArticle

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