Osteopontin: Its Properties, Recent Studies, and Potential Applications

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dc.authorid0000-0002-2913-2846
dc.contributor.authorKarasalih, Buesra
dc.contributor.authorDuman, Hatice
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T11:59:59Z
dc.date.available2026-02-03T11:59:59Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOPN is a phosphorylated glycoprotein found in all vertebrate organisms and expressed in many tissues and secretions. It is a pleiotropic protein that plays diverse roles in various pathological and physiological processes. OPN is involved in many tissue transformation events such as intestinal and brain development, the regulation of immune system activity, immune cell activation, and inflammatory responses. This protein increases the functionality of the digestive system by regulating the intestinal microbiome and may help strengthen the intestinal barrier. OPN can also influence cognitive development and behavior. In addition, its recent association with cancer has gained critical importance. The increased expression of OPN has been observed in many cancer types, which may promote tumor cell metastasis. OPN is also effective in bacterial interaction and infections; it can prevent bacterial adhesion, supporting the development of new therapeutic approaches for oral care. Furthermore, the supplementation of OPN in infant formula has positively influenced the immune and intestinal health of infants. Many recent studies have focused on these aspects. This article provides a review and comparison of the existing knowledge on the structure and functions of OPN. It emphasizes how milk-derived OPN impacts human and infant health and disease.
dc.identifier.doi10.3390/ijms26125868
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue12
dc.identifier.pmid40565331
dc.identifier.scopus2-s2.0-105009019985
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms26125868
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34462
dc.identifier.volume26
dc.identifier.wosWOS:001515932900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectosteopontin
dc.subjectbiomarker
dc.subjectcancer
dc.subjectinfant health
dc.subjectintestinal development
dc.subjecttemporal expression of cytokines
dc.subjectimmunomodulator
dc.subjectmilk
dc.titleOsteopontin: Its Properties, Recent Studies, and Potential Applications
dc.typeReview

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