Electrochemical oxidation of prednisolone at glassy carbon electrode and its quantitative determination in human serum and tablets by Osteryoung square wave voltammetry

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dc.authoridDilgin, Yusuf/0000-0002-2980-6871
dc.authoridSkrzypek, Slawomira/0000-0003-2037-5304
dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.contributor.authorYilmaz, Selahattin
dc.contributor.authorSkrzypek, Slowomira
dc.contributor.authorDilgin, Yusuf
dc.contributor.authorYagmur, Sultan
dc.contributor.authorCoskun, Mahmut
dc.date.accessioned2025-01-27T20:50:10Z
dc.date.available2025-01-27T20:50:10Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA simple, rapid, selective and sensitive electrochemical method for the direct determination of prednisolone in spiked human serum and tablets was developed. The electrochemical oxidation and determination of prednisolone has been carried out at glasy carbon electrode (GCE) in various aquaeous solution in the pH range of 0.56-12.30 by cyclic (CV) and Osteryoung square wave voltammetry (OSWV). The best results were obtained for the determination of prednisolone by OSWV method in 0.5 mol L-1 sulphuric acid at about pH 0.56. The peak current and peak potential depends on pH, so its influence and also scan rate were studied. The diffusion controlled by nature of the peak was established. This electroanalytical procedure enabled to determine prednisolone in the concentration range 1.0 X 10(-6)- 2.0 x 10(-5) mol L-1. This limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.4x10(-7) and 4.5x 10(-7) mol L-1 respectively. Precision and accuracy of the developed method were checked by recovery studies in spiked tablets and human serum.
dc.identifier.doi10.2174/157341107779314181
dc.identifier.endpage46
dc.identifier.issn1573-4110
dc.identifier.issue1
dc.identifier.scopus2-s2.0-33846334813
dc.identifier.scopusqualityQ2
dc.identifier.startpage41
dc.identifier.urihttps://doi.org/10.2174/157341107779314181
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25430
dc.identifier.volume3
dc.identifier.wosWOS:000243198200004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Analytical Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectprednisolone
dc.subjectvoltammetry
dc.subjectdetermination
dc.subjecttablet and serum
dc.titleElectrochemical oxidation of prednisolone at glassy carbon electrode and its quantitative determination in human serum and tablets by Osteryoung square wave voltammetry
dc.typeArticle

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