Investigation of the protective effects of L-carnitine and L-arginine on cardiovascular changes induced by ACTH and dexamethasone in rabbits

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dc.authoriduzun, metehan/0000-0003-1406-5473
dc.contributor.authorTopcu, Birkan
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:20:07Z
dc.date.available2025-01-27T20:20:07Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX). Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each. Blood samples were collected from all groups on days 1, 7, and 14, and blood pressure values and ECG monitoring were recorded. Nitric oxide (NO), creatine kinase MB (CK-MB), and troponin I (TnI) levels were determined in blood samples. Heart rate, QT, and corrected QT (QTc) values were calculated from ECG records. Results: The QT and QTc times were prolonged significantly (P < 0.001) in the ACTH-treated groups compared to the control group, and L-carnitine had no protective effect. Moreover, CK-MB (P < 0.05) and TnI (P < 0.001) levels were higher in the ACTH-treated groups than they were in the control group. Conclusion: Application of ACTH results in prolongation of QT and QTc intervals and increases in GK-MB and TnI levels, which are indicators of heart muscle damage.
dc.description.sponsorshipTUBITAK [TOVAG 107 O 617]
dc.description.sponsorshipThis study was supported by TUBITAK, project number: TOVAG 107 O 617.
dc.identifier.doi10.3906/sag-1204-47
dc.identifier.endpage173
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84872799615
dc.identifier.scopusqualityQ1
dc.identifier.startpage168
dc.identifier.trdizinid140882
dc.identifier.urihttps://doi.org/10.3906/sag-1204-47
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/140882
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21573
dc.identifier.volume43
dc.identifier.wosWOS:000321227400029
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectNitric oxide
dc.subjectQT
dc.subjectGK-MB
dc.subjecttroponin
dc.subjectACTH
dc.subjectcarnitine
dc.titleInvestigation of the protective effects of L-carnitine and L-arginine on cardiovascular changes induced by ACTH and dexamethasone in rabbits
dc.typeArticle

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