Profiling of apoptosis-associated proteins in human prostate cancer cells in response to Montivipera bulgardaghica albizona venom by protein array

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dc.authorid0000-0001-9323-9157en_US
dc.authorscopusid6602719986en_US
dc.authorwosidAAG-6778-2019en_US
dc.contributor.authorİlhan, Süleyman
dc.contributor.authorÇiçek, Kerim
dc.contributor.authorTok, Cemal Varol
dc.contributor.authorAtmaca, Harika
dc.date.accessioned2023-05-16T06:23:10Z
dc.date.available2023-05-16T06:23:10Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Biyoloji Bölümü
dc.description.abstractHere we studied the possible cytotoxic and apoptotic effects of Anatolian endemic mountain viper, Montivipera bulgardaghica albizona (M.b. albizona) venom on human PC-3 and DU-145 prostate cancer cell lines. M.b. albizona venom induced cytotoxicity and apoptosis of both prostate cancer cells in a concentration-dependent manner. Protein array results revealed that the levels of major components of the mitochondrion-initiated and the extrinsic death receptor-mediated pathways were significantly changed in prostate cancer cells by venom treatment. These data suggest that one or more of the purified components of the M.b. albizona venom may serve as an appropriate therapeutic agent for prostate cancer. Further bioactivity guided studies are required for the identification of bioactive compounds of M.b. albizona venom.en_US
dc.identifier.citationIlhan, S., Çiçek, K., Tok, C. V., & Atmaca, H. (2021). Profiling of apoptosis-associated proteins in human prostate cancer cells in response to montivipera bulgardaghica albizona venom by protein array. Toxin Reviews, 40(4), 1040-1047. doi:10.1080/15569543.2020.1826970en_US
dc.identifier.doi10.1080/15569543.2020.1826970
dc.identifier.endpage1047en_US
dc.identifier.issn1556-9543
dc.identifier.issn1556-9551
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85091726234
dc.identifier.startpage1040en_US
dc.identifier.urihttps://doi.org/10.1080/15569543.2020.1826970
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4157
dc.identifier.volume40en_US
dc.identifier.wosWOS:000573667400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTok, Cemal Varol
dc.language.isoen
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofToxin Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCytotoxicityen_US
dc.subjectMontivipera bulgardaghica albizonaen_US
dc.subjectProstate canceren_US
dc.subjectProtein arrayen_US
dc.titleProfiling of apoptosis-associated proteins in human prostate cancer cells in response to Montivipera bulgardaghica albizona venom by protein array
dc.typeArticle

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