A Novel Methodology for the Asymmetric Synthesis of 2,3,5-Trisubstituted Piperazine Derivatives

Basit Öğe Kaydı
dc.authoridDogan, Ozdemir/0000-0003-3724-8942
dc.contributor.authorBeksultanova, Nurzhan
dc.contributor.authorOzdemir, Ozge
dc.contributor.authorCakir, Sidika Polat
dc.contributor.authorAygun, Muhittin
dc.contributor.authorDogan, Ozdemir
dc.date.accessioned2025-01-27T20:11:47Z
dc.date.available2025-01-27T20:11:47Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPiperazines constitute an important structural feature of many pharmaceuticals. For the discovery of new drugs, the ability to modify the lead compound's structure is crucial. Herein, we provide an efficient method for the synthesis of chiral 2,3,5-trisubstituted piperazine structures. Our route enables the synthesis of several novel chiral aryl aziridinyl ketones that could be converted into aziridine-fused bicyclic imines. The reduction of these imines and the nucleophilic ring-opening reaction of the aziridine ring allowed us to synthesize highly functionalized piperazine derivatives.
dc.description.sponsorshipTrkiye Bilimsel ve Teknolojik Arascedil;timath;rma Kurumu
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1055/s-0040-1720114
dc.identifier.endpage2444
dc.identifier.issn0039-7881
dc.identifier.issn1437-210X
dc.identifier.issue15
dc.identifier.scopus2-s2.0-85190724905
dc.identifier.scopusqualityQ2
dc.identifier.startpage2432
dc.identifier.urihttps://doi.org/10.1055/s-0040-1720114
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20723
dc.identifier.volume56
dc.identifier.wosWOS:001199864800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofSynthesis-Stuttgart
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectpiperazines
dc.subjectasymmetric synthesis
dc.subjectaziridines
dc.subjectStaudinger reaction
dc.subjectintramolecular cyclization
dc.titleA Novel Methodology for the Asymmetric Synthesis of 2,3,5-Trisubstituted Piperazine Derivatives
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu