Hepatic effects of GLP-1 mimetics in diabetic milieu: A mechanistic review of involved pathways

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dc.contributor.authorYaribeygi, Habib
dc.contributor.authorKashian, Kiana
dc.contributor.authorMoghaddam, Kimia Imani
dc.contributor.authorKarim, Sheida Rashmeh
dc.contributor.authorBagheri, Narges
dc.contributor.authorKarav, Sercan
dc.contributor.authorJamialahmadi, Tannaz
dc.date.accessioned2025-01-27T20:32:07Z
dc.date.available2025-01-27T20:32:07Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPatients with diabetic are at a higher risk of developing hepatic disorders compared to non-diabetic individuals. This increased risk can be attributed to the diabetic environment, which triggers and exacerbates harmful pathways involved in both diabetic complications and hepatic disorders. Therefore, it is important to consider the use of antidiabetic agents that offer benefits beyond glycemic control and have positive effects on liver tissues. Glucagon-like peptide-1 (GLP-1) mimetics are a novel class of antidiabetic medications known for their potent blood sugar-lowering effects. Emerging evidence suggests that these drugs also have favorable effects on the liver. However, the precise effects and underlying mechanisms are not yet fully understood. In this review, we aim to provide a mechanistic perspective on the liver benefits of GLP-1 mimetics and outline the mediating mechanisms involved.
dc.identifier.doi10.1016/j.jdiacomp.2024.108928
dc.identifier.issn1056-8727
dc.identifier.issn1873-460X
dc.identifier.issue1
dc.identifier.pmid39644538
dc.identifier.scopus2-s2.0-85211043749
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2024.108928
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23355
dc.identifier.volume39
dc.identifier.wosWOS:001375737900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofJournal of Diabetes and Its Complications
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectKeywords
dc.subjectDiabetes mellitus
dc.subjectGLP-1
dc.subjectOxidative stress
dc.subjectInflammation
dc.subjectLiver
dc.subjectHepatic disorder
dc.subjectNAFLD
dc.titleHepatic effects of GLP-1 mimetics in diabetic milieu: A mechanistic review of involved pathways
dc.typeArticle

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