Relation of ASC and IL-1beta with neurocog-nitive parameters in patients with Obsessive-Compulsive Disorder

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dc.authoridONDER UZGAN, BETUL/0000-0002-6423-6704
dc.authoridAykac, Cansu/0000-0001-8702-5478
dc.authoridyaras, Tutku/0000-0003-3019-7900
dc.contributor.authorTetik, Melike
dc.contributor.authorUzgan, Betul Onder
dc.contributor.authorAykac, Cansu
dc.contributor.authorEkinci, Burcu
dc.contributor.authorYaras, Tutku
dc.contributor.authorKuruoglu, Aykut
dc.contributor.authorAkgul, Ozge
dc.date.accessioned2025-01-27T20:47:33Z
dc.date.available2025-01-27T20:47:33Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: It is now well accepted that inflammatory processes play a role in the etiopathogenesis of psychiatric disorders. NLRP3 inflammasome, which is formed by the combination of NLRP3, ASC and Caspase-1 proteins, and its activator NEK7, takes part in these processes. In this study, we aimed to investigate the relationship between inflammatory markers (i.e. IL-1 beta, IL-18, NLRP3 inflammasome protein levels) and cognitive functions in patients with obsessive compulsive disorder (OCD). Method: Forty-two patients between the ages of 18-45 who were diagnosed with OCD were included in the study. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Hamilton Depression Scale (HAMD) were used for clinical evaluations. In order to evaluate cognitive functions, Trail Making Test (TMT), Berg Card Sorting Test and Category Fluency Test were applied. IL-1 beta and IL-18 cytokine levels were determined by the ELISA method; measurement of the protein amounts of NLRP3, Caspase-1, ASC and NEK7 were performed by Western blotting. Results: Serum IL-1beta was negatively correlated with TMT (B-A) (rs=-.36, p= 0.019). Similarly, ASC was negatively correlated with TMT-B and TMT (B-A) (rs=-.38, p= 0.03; rs=-0.36, p = 0.04, respectively). However, no statistically significant relationship was found between other inflammatory parameters (NLRP3, Caspase-1, and IL-18) and neurocognitive tests. Discussion: Our results indicate that some aspects of neurocognitive impairment in patients with OCD might be related to neuroinflammatory processes, with implications for our understanding of the pathogenesis of OCD.
dc.description.sponsorshipTurkish Scientific and Technological Research Council TUBITAK [217S128]
dc.description.sponsorshipRole of Funding Sources This study was supported by the Turkish Scientific and Technological Research Council TUBITAK project 217S128 (TA) . TUBITAK had no further role in study design; in the collection, analysis and interpretation of data, in the writing of the report; and in the decision to submit the paper for publica-tion.
dc.identifier.doi10.5505/kpd.2022.72687
dc.identifier.endpage83
dc.identifier.issn1302-0099
dc.identifier.issn2146-7153
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85132036434
dc.identifier.scopusqualityQ4
dc.identifier.startpage75
dc.identifier.trdizinid529113
dc.identifier.urihttps://doi.org/10.5505/kpd.2022.72687
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/529113
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24956
dc.identifier.volume25
dc.identifier.wosWOS:000773101400008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKlinik Psikiyatri Dergisi
dc.relation.ispartofKlinik Psikiyatri Dergisi-Turkish Journal of Clinical Psychiatry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectOCD
dc.subjectNeuroinflammation
dc.subjectNLRP3
dc.subjectIL-1 beta
dc.subjectNeurocognition
dc.titleRelation of ASC and IL-1beta with neurocog-nitive parameters in patients with Obsessive-Compulsive Disorder
dc.typeArticle

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