The effect of 3-methylcholanthrene and butylated hydroxytoluene on glycogen levels of liver, muscle, testis, and tumor tissues of rats

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dc.authoridYelkuvan, Izzet/0000-0002-4668-2444
dc.authoridBingol, Gunsel/0000-0001-9834-0019
dc.contributor.authorPolat, Fikriye
dc.contributor.authorDere, Egemen
dc.contributor.authorGul, Eylem
dc.contributor.authorYelkuvan, Izzet
dc.contributor.authorOzdemir, Ozturk
dc.contributor.authorBingol, Gunsel
dc.date.accessioned2025-01-27T20:41:12Z
dc.date.available2025-01-27T20:41:12Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study examined the effects of separate and combined applications of 3-methylcholanthrene, a polycyclic aromatic hydrocarbon and potent carcinogenic agent, and butylated hydroxytoluene, the antioxidant food additive, on the glycogen levels of liver, muscle, testis, and tumor tissues in rats. Adult male Wistar albino rats weighing 100-110 g at 8 weeks of age were used in this study. This study consisted of a control group (n = 9) and 3 different experiment groups in which rats were chronically treated with 3-methylcholanthrene (n = 9) or butylated hydroxytoluene (n = 11) or a combination of these agents (n = 14). Rats were intraperitoneally injected with a 200 mg kg(-1) dose of butylated hydroxytoluene and a 40 mg kg-1 dose of 3-methylcholanthrene. At the end of the 26-week experimental period, tissues of rats killed via cervical dislocation were placed in 10% trichloroacetic acid for glycogen determination. Our results showed that the administration of 3-methylcholanthrene, butylated hydroxytoluene, and 3-methylcholanthrene + butylated hydroxytoluene caused statistically significant changes in the glycogen levels of liver, muscle, and testis tissues, and glycogen was stored in tumor tissue.
dc.identifier.doi10.3906/biy-1010-126
dc.identifier.endpage38
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84872734140
dc.identifier.scopusqualityQ1
dc.identifier.startpage33
dc.identifier.trdizinid140750
dc.identifier.urihttps://doi.org/10.3906/biy-1010-126
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/140750
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24062
dc.identifier.volume37
dc.identifier.wosWOS:000321227600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectGlycogen
dc.subject3-methylcholanthrene
dc.subjectbutylated hydroxytoluene
dc.subjectrat
dc.titleThe effect of 3-methylcholanthrene and butylated hydroxytoluene on glycogen levels of liver, muscle, testis, and tumor tissues of rats
dc.typeArticle

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