Does protocatechuic acid, a natural antioxidant, reduce renal ischemia reperfusion injury in rats?

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dc.authoridYuksel, Melih/0000-0002-0793-3693
dc.authoridyildar, murat/0000-0002-0367-8373
dc.contributor.authorYuksel, Melih
dc.contributor.authorYildar, Murat
dc.contributor.authorBasbug, Murat
dc.contributor.authorCavdar, Faruk
dc.contributor.authorCikman, Oztekin
dc.contributor.authorAksit, Hasan
dc.contributor.authorAslan, Figen
dc.date.accessioned2025-01-27T20:39:00Z
dc.date.available2025-01-27T20:39:00Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBACKGROUND: Protocatechuic acid (PCA), which has antioxidant property, is a simple phenolic compound commonly found in many plants, vegetables, and fruits, notably in green tea and almonds. Present study was an investigation of the effects of PCA on rat kidney with ischemia/reperfusion (IR) injury. METHODS: Sprague-Dawley rats were randomly divided into 4 groups: (1) Sham, (2) Renal IR, (3) Renal IR+ Vehicle, and (4) Renal IR+ PCA. Renal reperfusion injury was induced by clamping renal pedicle for 45 minutes after right nephrectomy was performed, followed by reperfusion for 3 hours. Dose of 80 mg/kg PCA was intraperitoneally administered to 1 group immediately before renal ischemia; 33% polyethylene glycol was used as vehicle. Total antioxidant status (TAS), malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 levels were measured in blood and kidney tissue samples taken from sacrificed rats. Kidney tissue samples were examined and scored histopathologically. Terminal deoxynucleotidyltransferase-mediated dUTP digoxigenin nick end labeling assay method was used to detect apoptotic cells. RESULTS: It was found that PCA significantly reduced serum MDA, TNF-alpha, and kidney MDA levels, while it increased serum and kidney TAS and SOD levels. Histopathological scores were significantly higher for the group given PCA. CONCLUSION: PCA reduced oxidative stress and can be used as an effective agent in treatment of renal IR injury.
dc.identifier.doi10.5505/tjtes.2016.20165
dc.identifier.endpage6
dc.identifier.issn1306-696X
dc.identifier.issue1
dc.identifier.pmid28261779
dc.identifier.scopus2-s2.0-85013115757
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.trdizinid275046
dc.identifier.urihttps://doi.org/10.5505/tjtes.2016.20165
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/275046
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23829
dc.identifier.volume23
dc.identifier.wosWOS:000396527500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgery
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAntioxidants
dc.subjectischemia reperfusion injury
dc.subjectmalondialdehyde
dc.subjectprotocatechuic acid
dc.subjectreactive oxygen species
dc.titleDoes protocatechuic acid, a natural antioxidant, reduce renal ischemia reperfusion injury in rats?
dc.title.alternativeDoğal bir antioksidan olan protokateşuik asit sıçanlarda renal iskemi reperfüzyon hasarını azaltıyor mu?
dc.typeArticle

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